271 Results for "

membrane function

" in MedChemExpress (MCE) Product Catalog:
Products (271)

271 Results for "membrane function" in MCE Product Catalog:

200
MitoTEMPO hydrate
MitoTEMPO hydrate
0 Images
200 Publications Verification
Cat. No.: HY-125944
CAS No.: 1569257-94-8
Purity:  98.03%
Target:  

Mitochondrial Metabolism PINK1/Parkin NOD-like Receptor (NLR) Autophagy Calcium Channel Apoptosis

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology

MitoTEMPO hydrate is a mitochondria-targeted antioxidant . MitoTEMPO hydrate induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. MitoTEMPO hydrate regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. MitoTEMPO hydrate reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. MitoTEMPO hydrate can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .
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200
Mito-TEMPO
Mito-TEMPO
0 Images
200 Publications Verification
Cat. No.: HY-112879
CAS No.: 1334850-99-5
Purity:  99.19%
Target:  

Calcium Channel PINK1/Parkin Mitochondrial Metabolism Apoptosis Autophagy NOD-like Receptor (NLR)

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology

Mito-TEMPO is a mitochondria-targeted antioxidant. Mito-TEMPO induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. Mito-TEMPO regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. Mito-TEMPO reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. Mito-TEMPO can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .
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191
DAPI dihydrochloride
DAPI dihydrochloride
0 Images
191 Cited Publications
Cat. No.: HY-D0814
CAS No.: 28718-90-3
Synonyms: 4',6-Diamidino-2-phenylindole dihydrochloride
DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
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191
DAPI
DAPI
0 Images
191 Cited Publications
Cat. No.: HY-D2868
CAS No.: 47165-04-8
Synonyms: 4',6-Diamidino-2-phenylindole
DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
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185
DAPI dilactate
DAPI dilactate
0 Images
185 Cited Publications
Cat. No.: HY-D1738
CAS No.: 28718-91-4
Synonyms: 4',6-Diamidino-2-phenylindole dilactate
DAPI (4',6-Diamidino-2-phenylindole) dilactate is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm) .
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102
Cholesterol (from animal)
Cholesterol (from animal)
0 Images
102 Cited Publications
Cat. No.: HY-N0322
CAS No.: 57-88-5
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Estrogen Receptor/ERR Bacterial Liposome

Cholesterol (from animal) is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol (from animal) plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol (from animal) is also an endogenous estrogen-related receptor α (ERRα) agonist .
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102
Cholesterol (Water Soluble)
Cholesterol (Water Soluble)
0 Images
102 Cited Publications
Cat. No.: HY-N0322A
Category:  

Lipids Endogenous metabolite

Target:  

Liposome

Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells .
(Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)
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72
Corticosterone
Corticosterone
0 Images
72 Cited Publications
Cat. No.: HY-B1618
CAS No.: 50-22-6
Synonyms: 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B
Category:  

Neurological Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:  

Glucocorticoid Receptor Endogenous Metabolite iGluR

Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .
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46
Rhod-2 AM
Rhod-2 AM
0 Images
46 Cited Publications
Cat. No.: HY-D0989
CAS No.: 145037-81-6
Rhod-2 is a high-affinity visible light excitation wavelength Ca 2+ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm .
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30
Linoleic acid
Linoleic acid
0 Images
30 Cited Publications
Cat. No.: HY-N0729
CAS No.: 60-33-3
Category:  

Cardiovascular Disease Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Biological Pesticide Research Agricultural Research

Target:  

Environmental Pollutants Endogenous Metabolite

Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
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22
L-Leucyl-L-Leucine methyl ester hydrochloride
L-Leucyl-L-Leucine methyl ester hydrochloride
0 Images
22 Cited Publications
Cat. No.: HY-129905
CAS No.: 6491-83-4
Purity:  98.92%
Synonyms: LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Caspase

L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrochloride is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrochloride can be used for research related to lysosomal function and apoptosis .
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22
L-Leucyl-L-Leucine methyl ester hydrobromide
L-Leucyl-L-Leucine methyl ester hydrobromide
0 Images
22 Cited Publications
Cat. No.: HY-129905A
CAS No.: 16689-14-8
Purity:  99.69%
Synonyms: LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Caspase

L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrobromide is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrobromide can be used for research related to lysosomal function and apoptosis .
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21
DOTAP methylsulfate
DOTAP methylsulfate
0 Images
21 Cited Publications
Cat. No.: HY-W127378
CAS No.: 144189-73-1
Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate
Target:  

Liposome

Research Areas:  

Others

DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .
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16
TAPI-1
TAPI-1
0 Images
16 Cited Publications
Cat. No.: HY-16657
CAS No.: 163847-77-6
Target:  

MMP NF-κB Apoptosis TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

TAPI-1 is a broad-spectrum MMP inhibitor and NF-κB p65 inhibitor that targets ADAM17/TACE, ADAM10 and other proteins. TAPI-1 reduces the proteolytic cleavage of membrane-bound TNF-α, decreases TNF-α levels, inhibits NF-κB pathway activation, and downregulates profibrotic markers. TAPI-1 reduces the proportion of proinflammatory immune cells, alleviates cardiac and airway fibrosis, and improves cardiac function after myocardial infarction. Meanwhile, TAPI-1 inhibits the viability, migration and invasion of esophageal squamous cell carcinoma cells, enhances the chemosensitivity of Cisplatin (HY-17394), induces apoptosis, and shows low toxicity to normal esophageal epithelial cells. TAPI-1 can be widely used in studies related to myocardial infarction-induced heart failure, severe traumatic tracheal stenosis, esophageal squamous cell carcinoma and other conditions .
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14
Cholesterol (synthetic)
Cholesterol (synthetic)
0 Images
14 Cited Publications
Cat. No.: HY-N0322E
CAS No.: 57-88-5
Target:  

Endogenous Metabolite Estrogen Receptor/ERR Bacterial Liposome

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cholesterol (synthetic) is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol (synthetic) plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol (synthetic) is also an endogenous estrogen-related receptor α (ERRα) agonist .
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14
Cholesterol (from plant)
Cholesterol (from plant)
0 Images
14 Cited Publications
Cat. No.: HY-N0322D
CAS No.: 57-88-5
Category:  

Dioscoreaceae Extract Plants 500 - Internal Server Error | MedChemExpress

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