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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
143 Results for "
membrane-bound
" in MedChemExpress (MCE) Product Catalog:
Products (143)
143 Results for "membrane-bound" in MCE Product Catalog:
37
37 Publications Verification
Target:
Research Areas:
IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ .
34
34 Cited Publications
Synonyms: Direct Blue 53; T-1824; C.I. 23860
Research Areas:
Evans Blue (Direct Blue 53; T-1824; C.I. 23860) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability .
16
16 Cited Publications
Cat. No.: HY-16657
CAS No.: 163847-77-6
Target:
Research Areas:
TAPI-1 is a broad-spectrum MMP inhibitor and NF-κB p65 inhibitor that targets ADAM17/TACE, ADAM10 and other proteins. TAPI-1 reduces the proteolytic cleavage of membrane-bound TNF-α, decreases TNF-α levels, inhibits NF-κB pathway activation, and downregulates profibrotic markers. TAPI-1 reduces the proportion of proinflammatory immune cells, alleviates cardiac and airway fibrosis, and improves cardiac function after myocardial infarction. Meanwhile, TAPI-1 inhibits the viability, migration and invasion of esophageal squamous cell carcinoma cells, enhances the chemosensitivity of Cisplatin (HY-17394), induces apoptosis, and shows low toxicity to normal esophageal epithelial cells. TAPI-1 can be widely used in studies related to myocardial infarction-induced heart failure, severe traumatic tracheal stenosis, esophageal squamous cell carcinoma and other conditions .
10
10 Cited Publications
Cat. No.: HY-P7365
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRG1; NRG1 Class VII Isoform Alpha 2a; Prev. HGL; NRG1 Class VII Isoform Beta 2a; Prev. NRG1-IT2; Neuregulin 1 Isoform HRG-Gamma; NDF; Neuregulin 1 Isoform HRG-Beta3; GGF; Neuregulin 1 Isoform HRG-Beta2; Pro-Neuregulin-1, membrane-bound Isoform; Neureguli
Species:
Human
Source:
E. coli
4
4 Cited Publications
Cat. No.: HY-W013093
CAS No.: 19817-92-6
Synonyms: UTP trisodium salt; Uridine 5'-triphosphate trisodium salt
Category:
Cardiovascular Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
2
2 Cited Publications
Cat. No.: HY-W009884
CAS No.: 2478-38-8
Category:
Microorganisms Monophenols Ketones, Aldehydes, Acids Other Diseases Phenols Plants Other Families Extract Disease Research Fields
Target:
2
Target:
Research Areas:
2
2
Research Areas:
Alkaline Phosphatase (Apase), Calf intestinal is an alkaline phosphatase from Calf intestinal, and is one of the most active alkaline phosphatases. Alkaline Phosphatase, Calf intestinal is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline Phosphatase, Calf intestinal reduces myeloperoxidase activity and bacterial translocation. Alkaline Phosphatase, Calf intestinal improves survival rate of mice infected with E. coli. Alkaline Phosphatase, Calf intestinal improves TNBS-induced colon inflammation .
2
2
Research Areas:
Alkaline Phosphatase (Apase), microorganism is an alkaline phosphatase from microorganism, and is one of the most active alkaline phosphatases. Alkaline phosphatase, microorganism is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, microorganism reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, microorganism improves survival rate of mice infected with E. coli. Alkaline phosphatase, microorganism improves TNBS-induced colon inflammation .
2
Research Areas:
Alkaline Phosphatase (Apase), Escherichia coli is an alkaline phosphatase from Escherichia coli, and is one of the most active alkaline phosphatases. Alkaline phosphatase, Escherichia coli is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Escherichia coli reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Escherichia coli improves survival rate of mice infected with E. coli. Alkaline phosphatase, Escherichia coli improves TNBS-induced colon inflammation .
2
Research Areas:
Alkaline Phosphatase (Apase), Chicken Intestine is an alkaline phosphatase from Chicken Intestine, and is one of the most active alkaline phosphatases. Alkaline phosphatase, Chicken Intestine is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Chicken Intestine reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Chicken Intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Chicken Intestine improves TNBS-induced colon inflammation .
2
2 Cited Publications
Cat. No.: HY-P72659A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FAP; Prolyl Endopeptidase FAP; Fibroblast Activation Protein Alpha; Dipeptidyl Peptidase FAP; Seprase; FAPalpha; DPPIV; SIMP; 170 KDa Melanoma membrane-bound Gelatinase; CDNA FLJ60298, Highly Similar To Seprase; Gelatine Degradation Protease FAP; Fibroblast Activation Protein, Alpha; Integral membrane Serine Protease; Serine Integral membrane Protease; Post-Proline Cleaving Enzyme; FAPA; Surface-Expressed Protease
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-13912G
CAS No.: 686770-61-6
1
1 Cited Publications
Cat. No.: HY-P77934
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: FAP; Prolyl Endopeptidase FAP; Fibroblast Activation Protein Alpha; Dipeptidyl Peptidase FAP; Seprase; FAPalpha; DPPIV; SIMP; 170 KDa Melanoma membrane-bound Gelatinase; CDNA FLJ60298, Highly Similar To Seprase; Gelatine Degradation Protease FAP; Fibroblast Activation Protein, Alpha; Integral membrane Serine Protease; Serine Integral membrane Protease; Post-Proline Cleaving Enzyme; FAPA; Surface-Expressed Protease
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P74709
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRG1; NRG1 Class VII Isoform Alpha 2a; Prev. HGL; NRG1 Class VII Isoform Beta 2a; Prev. NRG1-IT2; Neuregulin 1 Isoform HRG-Gamma; NDF; Neuregulin 1 Isoform HRG-Beta3; GGF; Neuregulin 1 Isoform HRG-Beta2; Pro-Neuregulin-1, membrane-bound Isoform; Neureguli
Species:
Canine
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-W157376
CAS No.: 155773-72-1
Target:
PAMAM Dendrimer G0.0 amine is a pore-forming channel antagonist, including anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC50 = 940 nM). At concentrations of 10 and 20 µM, PAMAM Dendrimer G0.0 amine reduces C2 toxin-induced death in HeLa cells. Additionally, PAMAM Dendrimer G0.0 amine is a chelator of nickel. In complexes with polysulfone membrane-bound chitosan, PAMAM Dendrimer G0.0 amine selectively captures and stores carbon dioxide (CO2) in a gas-feed system. PAMAM Dendrimer G0.0 amine has been used in the synthesis of PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). PAMAM Dendrimer G0.0 amine can be used in research related to infections, cancer, and drug delivery systems .
Cat. No.: HY-E70200
CAS No.: 99676-46-7
Target:
Research Areas:
Recombinant Kex2 protease is a membrane-bound, Ca 2+-dependent serine protease. Recombinant Kex2 protease specifically recognize and cleave the carboxyl-terminal peptide bonds of dibasic amino acids .
Synonyms: RXC004
Target:
Research Areas:
Zamaporvint (RXC004) is an orally active and selective inhibitor of Wnt. Zamaporvint targete membrane-bound o-acyltransferase Porcupine and inhibited Wnt ligand palmitoylation, secretion, and pathway activation. Zamaporvint displays a favorable pharmacokinetic profile and shows potent antiproliferative effects in Wnt ligand-dependent colorectal and pancreatic cell lines. Zamaporvint possesses multiple antitumor mechanisms and can be used in cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
