2250 Results for "

metabolism

" in MedChemExpress (MCE) Product Catalog:

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415

2-Deoxy-D-glucose

415 Publications Verification

Cat. No.: HY-13966

CAS No.: 154-17-6

Purity: 99.93%

Synonyms: 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose

Category:

Endogenous metabolite Disease Research Fields Saccharides Cancer Monosaccharides

Target:

Hexokinase HSV Apoptosis

2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

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234

AICAR phosphate

234 Cited Publications

Cat. No.: HY-13417A

CAS No.: 681006-28-0

Purity: 99.98%

Synonyms: Acadesine phosphate; AICA Riboside phosphate

Category:

Alkaloids Other Alkaloids Animal Disease Research Fields Cancer

Target:

AMPK Autophagy YAP Mitophagy Endogenous Metabolite

AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor .

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234

AICAR

234 Cited Publications

Cat. No.: HY-13417

CAS No.: 2627-69-2

Purity: 99.98%

Synonyms: Acadesine; AICA Riboside

Category:

Human Gut Microbiota Metabolites Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:

AMPK Autophagy YAP Mitophagy Endogenous Metabolite

AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR is also an autophagy, YAP and mitophagy inhibitor. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR inhibits autophagy through a mechanism independent of AMPK activity .

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197

Thiazolyl Blue

197 Cited Publications

Cat. No.: HY-15924

CAS No.: 298-93-1

Synonyms: MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide

Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .

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182

ATP

182 Cited Publications

Cat. No.: HY-B2176

CAS No.: 56-65-5

Synonyms: Adenosine 5'-triphosphate

Category:

Other Families Extract Endogenous metabolite Alkaloids Human Gut Microbiota Metabolites Plant Other Alkaloids Animal Microorganism Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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182

ATP dimagnesium

182 Cited Publications

Cat. No.: HY-B2176B

CAS No.: 74804-12-9

Synonyms: Adenosine 5'-triphosphate dimagnesium

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation. ATP dimagnesium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP dimagnesium has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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182

ATP disodium trihydrate

182 Cited Publications

Cat. No.: HY-B2176A

CAS No.: 51963-61-2

Synonyms: Adenosine-5'-triphosphate disodium trihydrate

Category:

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) disodium trihydrate is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation. ATP disodium trihydrate can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium trihydrate has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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179

ATP disodium salt

179 Cited Publications

Cat. No.: HY-B0345A

CAS No.: 987-65-5

Synonyms: Adenosine 5'-triphosphate disodium salt; Disodium adenosine triphosphate

Category:

Natural Products Plant Animal Other Families Extract Microorganism Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite

ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation .

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175

ATP disodium salt hydrate

175 Cited Publications

Cat. No.: HY-W010735

CAS No.: 34369-07-8

Synonyms: Adenosine 5'-triphosphate disodium salt hydrate

Category:

Plant Ketones, Aldehydes, Acids Animal Other Families Extract Microorganism Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) disodium salt hydrate is a central component of energy storage and metabolism in vivo. ATP disodium salt hydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt hydrate can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt hydrate has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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172

ATP dipotassium

172 Cited Publications

Cat. No.: HY-B2176C

CAS No.: 42373-41-1

Synonyms: Adenosine 5'-triphosphate dipotassium

Category:

Plant Ketones, Aldehydes, Acids Animal Other Families Extract Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) dipotassium is a central component of energy storage and metabolism in vivo. ATP dipotassium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation. ATP dipotassium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP dipotassium has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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172

ATP magnesium

172 Cited Publications

Cat. No.: HY-B2176E

CAS No.: 1476-84-2

Synonyms: Adenosine 5'-triphosphate magnesium

Target:

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) magnesium is a central component of energy storage and metabolism in vivo. ATP magnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP magnesium is an important endogenous signaling molecule in immunity and inflammation. ATP magnesium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP magnesium has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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172

ATP disodium salt, 100 mM Solution, PCR Grade

172 Cited Publications

Cat. No.: HY-B2176I

CAS No.: 987-65-5

Synonyms: Adenosine 5'-triphosphate disodium salt, 100 mM Solution, PCR Grade

ATP (Adenosine 5'-triphosphate) disodium salt, 100 mM Solution, PCR Grade is a central component of energy storage and metabolism in vivo. ATP disodium salt, 100 mM Solution, PCR Grade provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt, 100 mM Solution, PCR Grade is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt, 100 mM Solution, PCR Grade can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt, 100 mM Solution, PCR Grade has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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D-Glucose

65 Cited Publications

Cat. No.: HY-B0389

CAS No.: 50-99-7

Synonyms: Glucose; D-(+)-Glucose; Dextrose

Category:

Metabolic Disease Endogenous metabolite Disease Research Fields Sweeteners Saccharides Food Research Monosaccharides

Target:

Environmental Pollutants Endogenous Metabolite

D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .

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BAY-876

63 Cited Publications

Cat. No.: HY-100017

CAS No.: 1799753-84-6

Purity: 99.67%

Target:

GLUT Disulfidptosis

Research Areas:

Cancer

BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC₅₀ of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .

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Semaglutide

53 Cited Publications

Cat. No.: HY-114118

CAS No.: 910463-68-2

Purity: 99.84%

Target:

GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family

Research Areas:

Neurological Disease Metabolic Disease Cancer

Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

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Semaglutide acetate

53 Cited Publications

Cat. No.: HY-114118B

CAS No.: 1997361-85-9

Purity: 99.92%

Target:

GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family

Research Areas:

Neurological Disease Metabolic Disease Cancer

Semaglutide acetate is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide acetate promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide acetate also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide acetate has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide acetate can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

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Semaglutide TFA

53 Cited Publications

Cat. No.: HY-114118A

Purity: 99.92%

Target:

GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family

Research Areas:

Neurological Disease Metabolic Disease Cancer

Semaglutide TFA is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide TFA promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide TFA also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide TFA has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide TFA can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

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β-Glycerophosphate disodium salt hydrate

35 Cited Publications

Cat. No.: HY-126304

CAS No.: 154804-51-0

Purity: ≥98.0%

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Phosphatase Endogenous Metabolite ERK

β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .

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β-Glycerophosphate disodium salt pentahydrate

35 Cited Publications

Cat. No.: HY-D0886

CAS No.: 13408-09-8

Category:

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Phosphatase Endogenous Metabolite ERK

β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .

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Sodium dichloroacetate

34 Cited Publications

Cat. No.: HY-Y0445A

CAS No.: 2156-56-1

Target:

PDK-1 NKCC PDHK Reactive Oxygen Species (ROS) Apoptosis

Research Areas:

Cancer

Sodium dichloroacetate is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor. Sodium dichloroacetate also stimulates pyruvate dehydrogenase (PDH) activity and works as a Na ⁺-K ⁺-2Cl ⁻ cotransporter (NKCC) inhibitor. Sodium dichloroacetate prevents the phosphorylation of the E1α subunit of PDC, promoting the entry of pyruvate into the mitochondria for oxidative metabolism, reducing lactate production, and simultaneously increasing the production of reactive oxygen species (ROS). Sodium dichloroacetate inhibits tumor cell proliferation and induces apoptosis. Sodium dichloroacetate is promising for research of cancers .

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