4

CHPG

4 Cited Publications

Cat. No.: HY-101364

CAS No.: 170846-74-9

Purity: 99.51%

Target:

mGluR NF-κB ERK Akt

Research Areas:

Cardiovascular Disease Inflammation/Immunology

CHPG is a selective mGluR5 agonist, and attenuates SO₂-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells . CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways .

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4

CHPG sodium salt

4 Cited Publications

Cat. No.: HY-101364A

CAS No.: 1303993-73-8

Purity: 99.25%

Target:

mGluR NF-κB ERK Akt

Research Areas:

Neurological Disease Inflammation/Immunology

CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO₂-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells . CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways. .

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3

Phosphatidylserine

3 Cited Publications

Cat. No.: HY-A0183

CAS No.: 1446756-47-3

Synonyms: Phospholipids, phosphatidylserines; Serine glycerophosphatides

Category:

Animals

Target:

Akt TGF-β Receptor

Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses .

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3

STAT1/3-IN-1

3 Cited Publications

Cat. No.: HY-170621

CAS No.: 2958649-56-2

Target:

STAT NO Synthase COX Interleukin Related TNF Receptor

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

STAT1/3-IN-1 is a potent STAT1/3 inhibitor with potent anti-inflammatory effect. STAT1/3-IN-1 inhibits phosphorylation and nuclear translocation of STAT1/3 to modulate microglial inflammation, reduces LPS (HY-D1056)-induced pro-inflammatory cytokines (NO, IL-1β, IL-6, and TNF-α) and inflammatory mediators (iNOS, COX-2). STAT1/3-IN-1 exhibits low toxicity in mice. STAT1/3-IN-1 can be used for the research of neuroinflammation .

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2

Fremanezumab

2 Cited Publications

Cat. No.: HY-P99019

CAS No.: 1655501-53-3

Synonyms: TEV-48125; LBR-101; PF-04427429; RN-307

Fremanezumab (TEV-48125) is a humanized lgG2 monoclonal antibody that selectively and potently binds to calcitonin gene related peptide (CGRp) (IC₅₀ values = 7.943 nM). Fremanezumab binds to mouse CGRP with an IC₅₀ value of 19.6 nM. Fremanezumab counteracts anti-inflammatory effects of CGRP in vitro, including CGRP-mediated inhibition of LPS (HY-D1056)-induced microglial activation. Fremanezumab selectively inhibits the activation of Aδ meningeal nociceptors by cortical spreading depression (CSD) in rats. Fremanezumab can be used for the study of inflammation and chronic migraine .

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1

Geranylgeraniol

1 Cited Publications

Cat. No.: HY-W011474

CAS No.: 24034-73-9

Category:

Natural Products Microorganisms

Target:

NF-κB

Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

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1

NADPH oxidase-IN-1

1 Cited Publications

Cat. No.: HY-152026

CAS No.: 2762405-17-2

Purity: 99.60%

Target:

NADPH Oxidase

Research Areas:

Neurological Disease

NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC₅₀s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy .

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Chemerin15

Cat. No.: HY-P6442

CAS No.: 1020407-90-2

Target:

Chemerin Receptor Syk ERK Src p38 MAPK P-selectin

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury .

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