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1 Cited Publications

Category:

Cardiovascular Disease Human Gut Microbiota Metabolites Microorganisms Macrolide Antibiotics Antibiotics Disease Research Antibacterial Endogenous metabolite Disease Research Fields

Target:

Bacterial Apoptosis Fungal PI3K Akt TNF Receptor Interleukin Related

Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages .

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N-Nitrosonornicotine

Cat. No.: HY-W683760

CAS No.: 16543-55-8

Synonyms: (2S)-N'-Nitrosonornicotine

Target:

DNA/RNA Synthesis

Research Areas:

Cancer

N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts .

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Beauvericin-13C45

Cat. No.: HY-N6739S

Beauvericin- ¹³C₄₅ is ¹³C labeled Beauvericin (HY-N6739). Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages .

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N-Nitrosometoprolol

Cat. No.: HY-W726392

CAS No.: 138768-62-4

Target:

Adrenergic Receptor

Research Areas:

Endocrinology

N-Nitrosometoprolol is an N-nitroso derivative formed by the in vitro reaction of β-adrenergic blockers with sodium nitrite. N-Nitrosometoprolol can induce micronuclei in rat liver, bone marrow and spleen .

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7H-Dibenzo[c,g]carbazole

Cat. No.: HY-119983

CAS No.: 194-59-2

Purity: 99.98%

Synonyms: DBC

Target:

Environmental Pollutants Cytochrome P450

Research Areas:

Cancer

7H-Dibenzo[c,g]carbazole (DBC) is an azaarene with high lipophilicity. 7H-Dibenzo[c,g]carbazole has carcinogenic activity and induce DNA adducts in fish, DNA adducts, mutations in diploid human fibroblasts and micronuclei in human blood lymphocytes. 7H-Dibenzo[c,g]carbazole is activated by cytochrome P450 enzymes resulting mainly in the generation of phenolic metabolites .

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Beauvericin (Standard)

Cat. No.: HY-N6739R

CAS No.: 26048-05-5

Category:

Human Gut Microbiota Metabolites Microorganisms Macrolide Antibiotics Antibiotics Disease Research Antibacterial Endogenous metabolite

Target:

Reference Standards Bacterial Apoptosis Fungal PI3K Akt TNF Receptor Interleukin Related

Beauvericin (Standard) is the analytical standard of Beauvericin (HY-N6739). This product is intended for research and analytical applications. Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages .

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NU/ICRF 500

Cat. No.: HY-118379

CAS No.: 156074-08-7

Target:

Topoisomerase

Research Areas:

Inflammation/Immunology

NU/ICRF 500 is a topo II catalytic inhibitor which increases CREST negative micronuclei in human lymphocytes .

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N-Nitrosonornicotine-d4

Cat. No.: HY-W743781

CAS No.: 1426174-36-8

Synonyms: (2S)-N'-Nitrosonornicotine-d₄

N-Nitrosonornicotine-d₄ ((2S)-N'-Nitrosonornicotine-d₄) is deuterium labeled N-Nitrosonornicotine. N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts .

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Boc-AEVD-CHO TFA

Cat. No.: HY-P5834A

Target:

Caspase Apoptosis

Research Areas:

Inflammation/Immunology

Boc-AEVD-CHO TFA is a Caspase 8 inhibitor. Boc-AEVD-CHO TFA significantly increases the frequencies of Nocodazole (HY-13520) or methyl methane sulfonate (MMS) induced micronuclei (MN) and micronucleated binucleates (MNCB) in PBMC by inhibiting cell apoptosis. Boc-AEVD-CHO TFA can be used for immune and inflammatory diseases research .

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