35

β-Glycerophosphate disodium salt pentahydrate

35 Publications Verification

Category:

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Cancer

Target:

β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .

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35

β-Glycerophosphate disodium salt hydrate

35 Publications Verification

Cat. No.: HY-126304

CAS No.: 154804-51-0

Purity: ≥98.0%

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Phosphatase Endogenous Metabolite ERK

β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .

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5

Clodronic acid disodium salt

5 Cited Publications

Cat. No.: HY-B0657A

CAS No.: 22560-50-5

Synonyms: Clodronate disodium salt

Target:

Apoptosis

Research Areas:

Metabolic Disease Cancer

Clodronic acid (Clodronate) disodium salt is an orally active bisphosphonate. Clodronic acid disodium salt inhibits osteoclast-mediated bone resorption. Clodronic acid disodium salt reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid disodium salt is effective in the maintenance or improvement of bone mineral density. Clodronic acid disodium salt can be used for the research of multiple myeloma and postmenopausal osteoporosis .

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5

Eldecalcitol

5 Cited Publications

Cat. No.: HY-A0020

CAS No.: 104121-92-8

Synonyms: ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

Target:

VD/VDR Apoptosis

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1 .

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5

Clodronic acid

5 Cited Publications

Cat. No.: HY-B0657

CAS No.: 10596-23-3

Synonyms: Clodronate

Target:

Apoptosis

Research Areas:

Metabolic Disease Cancer

Clodronic acid (Clodronate) is an orally active bisphosphonate. Clodronic acid inhibits osteoclast-mediated bone resorption. Clodronic acid reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid is effective in the maintenance or improvement of bone mineral density. Clodronic acid can be used for the research of multiple myeloma and postmenopausal osteoporosis .

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5

Ibutamoren

5 Cited Publications

Cat. No.: HY-10199A

CAS No.: 159634-47-6

Purity: 98.52%

Synonyms: MK-677 free base; MK-0677 free base

Target:

GHSR Insulin Receptor

Research Areas:

Neurological Disease Metabolic Disease

Ibutamoren (MK-677 free base; MK-0677 free base) is an orally active non-peptide growth hormone secretagogue receptor agonist. Ibutamoren activates signal cascades by mimicking endogenous ligands, triggers pulsatile release of growth hormone from the pituitary gland, and increases serum levels of IGF-1 and insulin-like growth factor-binding protein 3. Ibutamoren not only increases the frequency of growth hormone pulses in male individuals, but also promotes elevated bone formation markers in female individuals with postmenopausal osteoporosis. The combination of Ibutamoren with Alendronate sodium hydrate (HY-11101) significantly increases bone mineral density at the femoral neck. However, Ibutamoren may cause mild, reversible adverse reactions such as increased appetite, fluid retention, and elevated fasting blood glucose. Ibutamoren has been widely used in studies related to idiopathic growth hormone deficiency, sarcopenia, Alzheimer's disease, and osteoporosis .

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