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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
64 Results for "
mitochondrial matrix
" in MedChemExpress (MCE) Product Catalog:
Products (64)
64 Results for "mitochondrial matrix" in MCE Product Catalog:
262
202
202 Cited Publications
Cat. No.: HY-W008923
CAS No.: 17086-28-1
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Doxycycline monohydrate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline monohydrate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline monohydrate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline monohydrate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline monohydrate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline monohydrate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .
29
29 Cited Publications
21
Target:
Research Areas:
MitoTracker Deep Red (MTDR) FM fluorescent dye that selectively accumulates in the mitochondrial matrix. MitoTracker Deep Red FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues. MitoTracker Deep Red dyes have an excitation/emission wavelength of 633/650-750 nm .
The Ex/Em of MitoTracker Deep Red (MTDR) FM is 644/665 nm.
The Ex/Em of MitoTracker Deep Red (MTDR) FM is 644/665 nm.
16
16 Cited Publications
Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
14
14 Cited Publications
Synonyms: α-Cyano-4-hydroxycinnamate
Target:
Research Areas:
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications .
2
2 Cited Publications
Synonyms: Palmitoyl CoA lithium
2
2 Cited Publications
Cat. No.: HY-P73917
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPD1; HuCHA60; Prev. SPG13; CPN60; HSP60; Spastic Paraplegia 13 (Autosomal Dominant); 60 KDa Heat Shock Protein, mitochondrial; Epididymis Secretory Sperm Binding Protein; mitochondrial matrix Protein P1; Heat Shock 60kD Protein 1 (Chaperonin); 60 KDa Ch
Species:
Human
Source:
E. coli
1
1
1 Cited Publications
Cat. No.: HY-W012550
CAS No.: 541-14-0
1
1 Cited Publications
Cat. No.: HY-P76185
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: C1QBP; Splicing Factor SF2-Associated Protein; Prev. HABP1; ASF/SF2-Associated Protein P32; Complement Component 1 Q Subcomponent-Binding Protein, mitochondrial; Glycoprotein GC1qBP; mitochondrial matrix Protein P32; SF2AP32; Hyaluronan-Binding Protein 1
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P73916
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: HSPD1; HuCHA60; Prev. SPG13; CPN60; HSP60; Spastic Paraplegia 13 (Autosomal Dominant); 60 KDa Heat Shock Protein, mitochondrial; Epididymis Secretory Sperm Binding Protein; mitochondrial matrix Protein P1; Heat Shock 60kD Protein 1 (Chaperonin); 60 KDa Chaperonin; Heat Shock 60kDa Protein 1 Isoform 2; Chaperonin 60; Heat Shock 60kDa Protein 1 Isoform 4; GroEL; Short Heat Shock Protein 60 Hsp60s1; Heat Shock 60kDa Protein 1 (Chaperonin); Heat Shock Protein 65; Heat Shock Protein Family D Member 1; HSP65; P60 Lymphocyte Protein; Hsp60; Heat Shock Protein 60; HLD4; Heat Shock Protein Family D (Hsp60) Member 1; HSP-60
Species:
Mouse
Source:
E. coli
Cat. No.: HY-W010520
CAS No.: 2682-20-4
Research Areas:
Methylothiazolinone is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone can cause mitochondrial damage in the endothelium of rat cerebral blood vessels .
Target:
Research Areas:
Citrate synthase is responsible for catalyzing the first reaction of the citric acid cycle: the condensation of acetyl-CoA and oxaloacetate to form citrate. Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix .
Solvent and concentration: DMSO: 1.5 mM
Cat. No.: HY-174374
CAS No.: 3076446-44-8
Target:
Research Areas:
Topobexin is a TOP2B-selective inhibitor with IC50 values of 0.19 μM and 4.8 μM for TOP2B and TOP2A (DNA decatenation assay). Topobexin binds to non-homologous residues in the obex pocket and targets the ATPase domain of TOP2B. Topobexin prevents anthracycline-induced DNA double-strand break formation, apoptotic signaling mediated by caspase 3/7, 8 and 9, cardiomyocyte morphological changes, mitochondrial depolarization/loss, left ventricular systolic dysfunction, extracellular matrix remodeling, fibrotic alterations, and increases in plasma cardiac troponin T and BNP. Topobexin does not impair the antiproliferative effects of anthracyclines in cancer cells, exhibits no intrinsic cytotoxicity in cardiomyocytes, and is well tolerated in rabbits. Topobexin can be used in studies related to anthracycline-induced cardiotoxicity .
Cat. No.: HY-DY1032
CAS No.: 201860-17-5
Solvent and concentration: DMSO: 1 mM
Cat. No.: HY-P3003
CAS No.: 157232-64-9
Category:
Target:
Research Areas:
Carnitine acetyltransferase is a mitochondrial matrix enzyme that catalyzes the interconversion of Acetyl-CoA and Acetylcarnitine (HY-126358). Carnitine acetyltransferase functions as a positive regulator of total body glucose tolerance and muscle activity of pyruvate dehydrogenase. Carnitine acetyltransferase is responsible for mitochondrial acetyl-CoA balance and regulation of fatty acid oxidation by utilizing short- and medium- chain fatty acids and their corresponding acylcarnitines as substrates. Carnitine acetyltransferase plays a crucial role in regulating glucose homeostasis. Carnitine acetyltransferase can be utilized in the research of aging, obesity, and diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
