1

1 Cited Publications

4-Di-1-ASP is a styryl dye used to stain glioma cells in living brain tissue for analysis of cell structure, viability, proliferation and endocytosis, cytokinesis and phagocytosis, as well as for observation of mitochondrial structures in living cells. 4-Di-1-ASP fluoresces green when imaged microscopically (λ_ex /λ_em = 475/606 nm) .

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Plecstatin-1 hydrochloride

1 Cited Publications

Cat. No.: HY-156675A

Purity: 99.34%

Target:

Microtubule/Tubulin Eukaryotic Initiation Factor (eIF) HSP Caspase Reactive Oxygen Species (ROS) Apoptosis

Research Areas:

Cancer

Plecstatin-1 hydrochloride is a metal complex that drives the aggregation and collapse of the plectin network, and disrupts the cytoskeletal structures of α‑tubulin and F‑actin. Plecstatin-1 hydrochloride triggers oxidative stress, mediates the phosphorylation of eIF2α, and induces molecular features associated with immunogenic cell death, including calreticulin membrane exposure, membrane localization of HSP70/HSP90, ATP secretion, and HMGB‑1 release. Plecstatin-1 hydrochloride induces apoptosis via the intrinsic mitochondrial pathway and exerts anti-invasive activity. Plecstatin-1 hydrochloride inhibits sphere proliferation and reduces clonogenicity in the 3D tumor spheroid model of colon cancer cells. Plecstatin-1 hydrochloride is applicable to relevant research on colorectal cancer .

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Fusaric acid

Cat. No.: HY-128483

CAS No.: 536-69-6

Purity: 99.94%

Category:

Infection Microorganisms Ketones, Aldehydes, Acids Disease Research Fields

Target:

TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor

Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

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Scoulerine

Cat. No.: HY-N1255

CAS No.: 6451-73-6

Synonyms: (-)-Scoulerine; Discretamine

Category:

Alkaloids Phenols Polyphenols Plants Other Families Extract Disease Research Fields Isoquinoline Alkaloids Cancer

Target:

Bcl-2 Family Apoptosis mTOR GABA Receptor PI3K Adrenergic Receptor Beta-secretase Akt

Scoulerine ((-)-Scoulerine; Discretamine) hydrochloride is a multi-target inhibitor with anti-tumor and antioxidant activities. Scoulerine mainly targets the PI3K/Akt/mTOR signaling axis and α1D-adrenergic receptor, disrupts microtubule structure, and induces cell cycle arrest and apoptosis. Scoulerine effectively inhibits mitochondrial dehydrogenase activity, targets GABA receptors and BACE1, and suppresses the proliferation, migration, invasion, epithelial-mesenchymal transition and stem cell properties of cancer cells. Scoulerine also exhibits multiple pharmacological activities including anti-Plasmodium falciparum, antibacterial, antiemetic and antitussive effects, and regulates endoplasmic reticulum stress and mitochondrial function (modulates Bax, Bcl-2 and cytochrome c). Scoulerine is applicable to research related to leukemia, ovarian cancer, and colorectal cancer .

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L-Cytidine

Cat. No.: HY-148165

CAS No.: 26524-60-7

Purity: ≥98.0%

Target:

Nucleoside Antimetabolite/Analog Drug Isomer DNA/RNA Synthesis

Research Areas:

Neurological Disease Metabolic Disease

L-Cytidine is the L-configurational form of Cytidine (HY-B0158). L-Cytidine is a pyrimidine nucleoside and a component of RNA. Cytidine regulates glial glutamate cycling, affects cephalin metabolism, catecholamine synthesis and mitochondrial function. L-Cytidine interacts with HSA, which may alter the structure and function of HSA .

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HYL001

Cat. No.: HY-160237

CAS No.: 2426547-83-1

Target:

Anaplastic lymphoma kinase (ALK) Glutaminase ATP Synthase Mitochondrial Metabolism Apoptosis Reactive Oxygen Species (ROS)

Research Areas:

Cancer

HYL001 is an orally active, selective ALK4/ALK5 inhibitor with K_d values of 13 nM and 22.5 nM for ALK4 and ALK5, respectively. HYL001 inhibits GLS expression. HYL001 impairs glutamine metabolism, mitochondrial respiration, the TCA cycle, oxidative phosphorylation, ATP production, and redox balance, while selectively targeting mitochondria, disrupting mitochondrial structure, and inducing Apoptosis and ROS. HYL001 inhibits tumor growth and liver metastasis. HYL001 can be used in research on breast cancer, hepatocellular carcinoma, and microsatellite-stable colorectal cancer metastasis .

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Clomazone

Cat. No.: HY-W040194

CAS No.: 81777-89-1

Target:

Environmental Pollutants Herbicide

Research Areas:

Metabolic Disease

Clomazone is a broad spectrum herbicide, mainly used to control annual broadleaf weeds and grass weeds in various crops such as rice, soybeans, and peanuts. Clomazone inhibits carotenoid biosynthesis, and treated plants show typical "albinism" symptoms due to the destruction of chloroplast membrane structure leading to chlorophyll degradation. Clomazone exhibits multiple toxic effects on non-target organisms, including aquatic lethality, developmental malformations, liver damage, mitochondrial dysfunction, and hematotoxicity .

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11(Z),14(Z),17(Z)-Eicosatrienoic acid

Cat. No.: HY-108398B

CAS No.: 17046-59-2

Purity: 99.30%

Category:

Microorganisms Ketones, Aldehydes, Acids

Target:

Endogenous Metabolite

11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid is an unsaturated fatty acid that affects mitochondrial genome maintenance. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid fully incorporates into cell membrane phospholipids and supports the initial induction of cellular respiration, but fails to sustain the continuous replication and retention of mitochondrial genomes. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid is applicable to research related to fatty acid acyl chain structure-dependent mitochondrial genome maintenance and mitochondrial biogenesis .

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Methylene Violet 3RAX

Cat. No.: HY-W130236

CAS No.: 4569-86-2

Target:

Cholinesterase (ChE)

Research Areas:

Cancer

Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an K_is of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy) .

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Physalin B

Cat. No.: HY-N7695

CAS No.: 23133-56-4

Category:

Ketones, Aldehydes, Acids Plants Other Families Extract Disease Research Fields Cancer

Target:

Apoptosis NF-κB NOD-like Receptor (NLR) STAT PI3K Akt Hedgehog GSK-3 p38 MAPK ERK JNK Keap1-Nrf2 Reactive Oxygen Species (ROS) Autophagy

Physalin B is an orally active anti-inflammatory and anticancer agent. Physalin B can be isolated from Physalis alkekengi L. var. Franchetii. Physalin B inhibits the activation of the NF-κB, NLRP3 inflammasome, STAT3, PI3K/Akt and Hedgehog signaling pathways, regulates the phosphorylation levels of GSK-3β, p38 MAPK, ERK1/2 and JNK, and promotes the nuclear translocation of NRF2. Physalin B reduces the levels of pro-inflammatory cytokines and factors, induces mitochondrial reactive oxygen species (mito-ROS) production, Apoptosis, G2/M cell cycle arrest and incomplete Autophagy, alters cytoskeleton structure and alleviates oxidative stress. Physalin B reduces cancer cell viability, ameliorates liver and lung tissue damage and alleviates liver fibrosis. Physalin B can be used in research related to ulcerative colitis, breast cancer, acute lung injury, colon cancer, non-alcoholic steatohepatitis, liver fibrosis, lung cancer, pancreatic cancer, lymphoma, ovarian cancer, sarcoma and leukemia .

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P259

Cat. No.: HY-P11005

Target:

Dynamin ATP Synthase

Research Areas:

Neurological Disease

P259 is a Drp1-Mff inhibitor. P259 distinguishes physiological from pathological fission by specifically inhibiting Drp1-Mff interaction. P259 elongates cell mitochondria and disrupts mitochondrial function and motility. P259 reduces ATP levels and alters mitochondrial structure in the brain, resulting in behavioral deficits in wild-type mice and a short lifespan in Huntington's disease (HD) mice model .

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CAD031

Cat. No.: HY-124609

CAS No.: 2071209-49-7

Purity: 99.39%

Target:

AMPK Acetyl-CoA Carboxylase

Research Areas:

Neurological Disease

CAD031 is an orally active AMPK/ACC1 signaling pathway activator and a derivative of the Alzheimer's disease (AD) targeted agent J147 (HY-13779) (more active than J147 in human neural stem cell assays). CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimer's disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice .

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Opitor-0

Cat. No.: HY-177306

Target:

Dynamin Apoptosis

Research Areas:

Cancer

Opitor-0 is a OPA1 GTPase inhibitor with an IC₅₀ of 3.0 μM. Opitor-0 disrupts mitochondrial cristae structure and respiratory efficiency, induces mitochondrial fragmentation, enhances cBID-mediated cytochrome c release, and restores the sensitivity of triple-negative breast cancer (TNBC) cells to ABT-737 (HY-50907). Opitor-0 selectively reduces the migration and proliferation capacities of metastatic breast cancer cells, and induces cell death and apoptosis. Opitor-0 can be used in studies related to metastatic breast cancer and triple-negative breast cancer .

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