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262 Results for "

mitogen-activated

" in MedChemExpress (MCE) Product Catalog:

Products (262)

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Conivaptan hydrochloride

14 Publications Verification

Cat. No.: HY-18347A

CAS No.: 168626-94-6

Synonyms: YM 087

Target:

Vasopressin Receptor Cytochrome P450

Conivaptan hydrochloride (YM 087) is an orally active dual vasopressin V_1a/V₂ receptor antagonist with K_i values of 0.48 nM and 3.04 nM for vasopressin V_1a receptor and V₂ receptor, respectively. Conivaptan hydrochloride competitively and reversibly blocks vasopressin-mediated antidiuresis, vasoconstriction, and cellular hypertrophy, while inhibiting CYP3A4. Conivaptan hydrochloride inhibits vasopressin-induced intracellular calcium, cAMP, and mitogen-activated kinase activation in vascular smooth muscle cells and cardiomyocytes. Conivaptan hydrochloride induces water diuresis while improving hemodynamics in heart failure models, reducing left ventricular end-diastolic pressure, vascular resistance, and organ weight. Conivaptan hydrochloride is used for research on hyponatremia and congestive heart failure .

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NSC 95397

9 Cited Publications

Cat. No.: HY-108543

CAS No.: 93718-83-3

Purity: ≥99.0%

Target:

Phosphatase Apoptosis

Research Areas:

Cancer

NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (K_i=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC₅₀=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B)) . NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway .

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ERK1/2 Antibody (YA453)

7 Cited Publications

Cat. No.: HY-P80393

Synonyms: ERK1, PRKM3, MAPK3, mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, Microtubule-associated protein 2 kinase, p44-ERK1, ERK-1, p44-MAPK, ERK2, PRKM1, PRKM2, MAPK1, mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, MAP kinase isoform p42, mitogen-activated protein kinase 2, ERK-2, p42-MAPK, MAP kinase 2, MAPK 2

Host:

Rabbit

Application:

WB, ICC/IF, IP, FC

Reactivity:

Human, Mouse, Rat

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