26

GW806742X

26 Cited Publications

Cat. No.: HY-112292

CAS No.: 579515-63-2

Purity: 99.33%

Target:

Mixed Lineage Kinase VEGFR

Research Areas:

Others

GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K_d of 9.3 μM. GW806742X has activity against VEGFR2 (IC₅₀=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis .

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26

GW806742X hydrochloride

26 Cited Publications

Cat. No.: HY-112292A

CAS No.: 2930350-95-9

Purity: 98.77%

Target:

Mixed Lineage Kinase VEGFR

Research Areas:

Cancer

GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K_d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 (IC₅₀=2 nM). GW806742X hydrochloride retards MLKL membrane translocation and inhibits necroptosis .

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17

MPP hydrochloride

17 Cited Publications

Cat. No.: HY-103454B

CAS No.: 2863676-89-3

Purity: 99.28%

Target:

Estrogen Receptor/ERR Apoptosis

Research Areas:

Endocrinology Cancer

MPP hydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP hydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP hydrochloride reverses the the positive effects of beta-estradiol. MPP hydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo .

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17

MPP dihydrochloride

17 Cited Publications

Cat. No.: HY-103454

CAS No.: 911295-24-4

Purity: 99.54%

Target:

Estrogen Receptor/ERR Apoptosis

Research Areas:

Endocrinology Cancer

MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo .

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11

Spermine

11 Cited Publications

Cat. No.: HY-B1777

CAS No.: 71-44-3

Synonyms: NSC 268508; Neuridine

Category:

Human Gut Microbiota Metabolites Natural Products Microorganisms Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis

Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine inhibits primary human embryo lung fibroblasts in vitro .

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11

Spermine tetrahydrochloride

11 Cited Publications

Cat. No.: HY-B1777A

CAS No.: 306-67-2

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis

Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .

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10

GW280264X

10 Cited Publications

Cat. No.: HY-115670

CAS No.: 866924-39-2

Purity: 99.30%

Target:

MMP

Research Areas:

Inflammation/Immunology Cancer

GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC₅₀s of 8.0 nM and 11.5 nM, respectively . ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells .

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10

Brincidofovir

10 Cited Publications

Cat. No.: HY-14532

CAS No.: 444805-28-1

Purity: 99.46%

Synonyms: CMX001; HDP-CDV

Target:

CMV HSV Orthopoxvirus

Research Areas:

Infection

Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo .

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8

NOD-IN-1

8 Cited Publications

Cat. No.: HY-100691

CAS No.: 132819-92-2

Purity: 99.48%

Target:

NOD-like Receptor (NLR)

Research Areas:

Inflammation/Immunology

NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC₅₀ of 5.74 μM and 6.45 μM, respectively.

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7

URMC-099

7 Cited Publications

Cat. No.: HY-12599

CAS No.: 1229582-33-5

Purity: 99.34%

Target:

Mixed Lineage Kinase Autophagy

Research Areas:

Neurological Disease Cancer

URMC-099 is an orally bioavailable and potent mixed lineage kinase type 3 (MLK3) (IC₅₀=14 nM) inhibitor with with excellent blood-brain barrier penetration properties.

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6

5(6)-Carboxyfluorescein

6 Cited Publications

Cat. No.: HY-15940

CAS No.: 72088-94-9

Synonyms: 5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed isomers

5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo .

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