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26 Results for "

mouse brain tissue

" in MedChemExpress (MCE) Product Catalog:

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AS 1411

3 Cited Publications

Cat. No.: HY-147081

CAS No.: 301636-59-9

Purity: 99.52%

Synonyms: AGRO-100

Target:

Histone Methyltransferase Bcl-2 Family

Research Areas:

Cancer

AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .

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AS 1411 sodium

3 Cited Publications

Cat. No.: HY-147081A

Synonyms: AGRO-100 sodium

Target:

Histone Methyltransferase Bcl-2 Family

Research Areas:

Cancer

AS 1411 (AGRO-100) sodium is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 sodium inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 sodium reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. S 1411 sodium works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. S 1411 sodium-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity

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Arundic Acid

2 Cited Publications

Cat. No.: HY-107661

CAS No.: 185517-21-9

Purity: ≥98.0%

Synonyms: ONO-2506; (R)-2-Propyloctanoic acid

Target:

ERK Akt NF-κB EAAT

Research Areas:

Cardiovascular Disease Neurological Disease

Arundic Acid is an orally effective astrocyte function modulator and neuroprotective agent. Arundic Acid increases the expression and function of the astrocytic glutamate transporter EAAT1 by activating the ERK, Akt and NF-κB pathways. Arundic Acid attenuates retinal ganglion cell death in a normal-tension glaucoma model. Arundic Acid exerts neuroprotective effects in a mouse model of Parkinson's disease. Arundic Acid is a S100β protein synthesis inhibitor that prevents neurological deficits and brain tissue damage after intracerebral hemorrhage in rats. Arundic Acid downregulates neuroinflammation and astrocytic dysfunction after status epilepticus in immature rats. Arundic Acid is applicable to research related to Parkinson's disease, cerebral ischemia, glaucoma, intracerebral hemorrhage and epilepsy .

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FFN246

1 Cited Publications

Cat. No.: HY-149170

CAS No.: 2210244-83-8

Purity: 99.79%

Target:

5-HT Receptor Monoamine Transporter

Research Areas:

Neurological Disease

FFN246 is a fluorescent, dual substrate of serotonin transporter (SERT) probe and vesicular monoamine transporter 2 (VMAT2) with excitation and emission spectra 392/427 nm. FFN246 can be used for labeling serotonergic neurons in mouse brain tissue through SERT-dependent accumulation .

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