63 Results for "

mouse fibroblasts

" in MedChemExpress (MCE) Product Catalog:
Products (63)

63 Results for "mouse fibroblasts" in MCE Product Catalog:

6
(±)-BI-D
(±)-BI-D
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6 Publications Verification
Cat. No.: HY-18601
CAS No.: 1416258-16-6
Target:  

HIV HIV Integrase

Research Areas:  

Infection

(±)-BI-D is a potent ALLINI (allosteric integrase inhibitor). (±)-BI-D binds integrase at the LEDGF/p75 binding site. (±)-BI-D inhibits HIV-Luc infection in cells (IC50: 0.16 μM in Psip1 knockout E9 mouse embryonic fibroblasts, 2.9 μM in wild-type E9 mouse embryonic fibroblasts) .
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5
KGF-2/FGF-10 Protein, Mouse
KGF-2/FGF-10 Protein, Mouse
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5 Cited Publications
Cat. No.: HY-P7170
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF10; Produced By fibroblasts Of Urinary Bladder Lamina Propria; Fibroblast Growth Factor 10; Fibroblast Growth Factor; Keratinocyte Growth Factor 2; LADD3; FGF-10; FGF
Species:  
Mouse
Source:  
E. coli
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3
TC-I 15
TC-I 15
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3 Cited Publications
Cat. No.: HY-107588
CAS No.: 916734-43-5
Purity:  99.94%
Target:  

Integrin

Research Areas:  

Cardiovascular Disease

TC-I 15 (TC-I-15) is a type of allosteric collagen-binding integrin α2β1 inhibitor, and it also inhibits α1β1 and α11β1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast (CAF) extracellular vesicles (EVs) by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma (SACC) to the lungs in mouse models, .
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1
M47
M47
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1 Cited Publications
Cat. No.: HY-148764
CAS No.: 890808-56-7
Purity:  99.90%
Target:  

Cryptochrome Molecular Glues Apoptosis

Research Areas:  

Cancer

M47 is a molecular glue that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer .
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1
KL1333
KL1333
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1 Cited Publications
Cat. No.: HY-128895
CAS No.: 1800405-30-4
Purity:  99.94%
Target:  

Quinone Reductase Mitochondrial Metabolism

Research Areas:  

Metabolic Disease

KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures .
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Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10)
Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10)
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Cat. No.: HY-P990117
Target:  

Integrin

Research Areas:  

Cardiovascular Disease Cancer

Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) is a mouse-derived Osteopontin/SPP1 IgG1 κ type antibody inhibitor. Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) blocks Angiotensin II (HY-13948)-induced DNA synthesis and collagen gel contraction in cardiac fibroblasts. Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) significantly inhibits tumor growth in CT26 or MC38 tumors mice models .
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Cholestenone
Cholestenone
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Cat. No.: HY-113365
CAS No.: 601-57-0
Purity:  99.81%
Synonyms: 4-Cholesten-3-one
Category:  

Microorganisms Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite

Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent that is metabolized primarily in the liver as an intermediate oxidation product of cholesterol. Cholestenone inhibits human dermal fibroblast migration and fights Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also alleviates metabolic disorders caused by obesity in db/db mice .
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CYT296
CYT296
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Cat. No.: HY-141591
CAS No.: 1799392-31-6
Purity:  99.80%
Target:  

Biochemical Assay Reagents

Research Areas:  

Others

CYT296 is a target chromatin de-condensation compound. CYT296 can improve the induction of induced pluripotent stem cell (iPSCs) mediated by defined factors (OSKM) and induce an open chromatin state in Mouse Embryonic Fibroblast (MEFs) to facilitate somatic cell reprogramming. CYT296 can be used for cell replacement therapies and drug screening research .
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1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe
1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe
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Cat. No.: HY-115701
CAS No.: 154436-49-4
Synonyms: 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine; 15(S)-HpETE-SAPE; 15(S)-hydroperoxyeicostetraenoic acid-SAPE
Target:  

Ferroptosis

Research Areas:  

Inflammation/Immunology

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.
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MEISi-1
MEISi-1
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Cat. No.: HY-134258
CAS No.: 446306-43-0
Purity:  98.76%
Target:  

HOXA

Research Areas:  

Cardiovascular Disease Cancer

MEISi-1 is a small-molecule inhibitor targeting the homeodomain of the MEIS1 protein. MEISi-1 significantly inhibits the activity of luciferase reporter genes containing MEIS binding sites (TGACAG), and induces the self-renewal of a key type of mouse and human hematopoietic stem cells (HSC) both in vitro and in vivo. MEISi-1 promotes cardiomyocyte proliferation and cytokinesis, reduces cardiac fibroblast proliferation, and upregulates the expression of cardiomyocyte-specific genes. MEISi-1 can be used in research on hematological diseases, cardiac regeneration and cancer .
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NCI-006
NCI-006
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Cat. No.: HY-176798
CAS No.: 1964516-64-0
Target:  

Lactate Dehydrogenase Reactive Oxygen Species (ROS) Apoptosis

Research Areas:  

Cancer

NCI-006 is an orally active lactate dehydrogenase (LDH) inhibitor (LDHA IC50 = 0.06 μM; LDHB IC50 = 0.03 μM). NCI-006 inhibits intratumoral LDH activity, lactate production, and tumor growth in a mouse pancreatic cancer model. NCI-006 inhibits glycolysis and induces apoptosis in vitro. NCI-006 enhances the radiosensitivity of glycolytic tumor cell lines while sparing non-glycolytic/normal cells (1522, skin fibroblasts) in combination with ionizing radiation (IR). NCI-006 exhibits synergistic antitumor effects in combination with IACS-010759 (HY-112037) against colorectal and gastric cancers. NCI-006 targets glycolysis by inhibiting lactate dehydrogenase impairs tumor growth in an Ewing sarcoma model .
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H-Hyp-Gly-OH
H-Hyp-Gly-OH
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Cat. No.: HY-P4550
CAS No.: 7672-35-7
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

H-Hyp-Gly-OH is a dipeptide containing hydroxyproline and glycine. H-Hyp-Gly-OH promotes the growth of mouse primary fibroblasts on collagen gel. H-Hyp-Gly-OH has potential applications in improving skin by ingesting hydrolyzed collagen. H-Hyp-Gly-OH can be used for metabolic research .
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TNF-α-IN-18
TNF-α-IN-18
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Cat. No.: HY-164102
CAS No.: 1272322-42-5
Target:  

TNF Receptor NF-κB

Research Areas:  

Inflammation/Immunology

TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis .
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PPIase-Parvulin inhibitor
PPIase-Parvulin inhibitor
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Cat. No.: HY-128034
CAS No.: 64005-90-9
Purity:  99.79%
Target:  

PIN1

Research Areas:  

Cancer

PPIase-Parvulin inhibitor (compound B) is a cell-permeable inhibitor targeting PPIase Pin1 and Par14, with IC50s of 1.5 and 1.0 µM, respectively. PPIase-Parvulin inhibitor has anticancer activity and inhibits the growth and proliferation of mouse embryonic fibroblasts (MEFs) .
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Kras4B G12D-IN-1
Kras4B G12D-IN-1
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Cat. No.: HY-153413
CAS No.: 2042365-85-3
Purity:  98.01%
Target:  

Ras

Research Areas:  

Cancer

Kras4B G12D-IN-1 is a Kras4B G12D inhibitor with anticancer effects. Kras4B G12D-IN-1 decreases Kras protein expression in mouse embryonic fibroblasts (MEF) expressing Kras4B G12D (WO2016179558A1, Comp 994566) .
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UC-857993
UC-857993
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Cat. No.: HY-124514
CAS No.: 487001-04-7
Target:  

SOS1 Ras ERK

Research Areas:  

Cancer

UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs) .
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Cholestenone (Standard)
Cholestenone (Standard)
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Cat. No.: HY-113365R
CAS No.: 601-57-0
Synonyms: 4-Cholesten-3-one (Standard)
Category:  

Microorganisms Endogenous metabolite Steroids

Target:  

Reference Standards Endogenous Metabolite

Cholestenone (Standard) (4-Cholesten-3-one (Standard)) is the analytical standard of Cholestenone (HY-113365). This product is intended for research and analytical applications. Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent that is metabolized primarily in the liver as an intermediate oxidation product of cholesterol. Cholestenone inhibits human dermal fibroblast migration and fights Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also alleviates metabolic disorders caused by obesity in db/db mice .
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NPD-2975
NPD-2975
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Cat. No.: HY-155732
CAS No.: 3032452-65-3
Target:  

Parasite

Research Areas:  

Infection

NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC500 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC50 values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively .
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C-Type Natriuretic Peptide (1-53), Porcine, Rat,mouse
C-Type Natriuretic Peptide (1-53), Porcine, Rat,mouse
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Cat. No.: HY-P10720
CAS No.: 129405-72-7
Target:  

Endogenous Metabolite

Research Areas:  

Cardiovascular Disease

C-Type Natriuretic Peptide (1-53), Porcine, Rat, mouse is an activator of particulate guanylate cyclase B (pGC-B), which is highly expressed in endothelial cells, kidneys, and the heart. C-Type Natriuretic Peptide (1-53), Porcine, Rat, mouse can mediate a potent anti-fibrotic effect in human cardiac and renal fibroblasts by generating the second messenger cGMP .
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Aristolactam BIII
Aristolactam BIII
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Cat. No.: HY-122989
CAS No.: 53948-10-0
Category:  

Alkaloids Annonaceae Extract Other Alkaloids 500 - Internal Server Error | MedChemExpress

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