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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
mouse islet cells
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "mouse islet cells" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: 5,6-EET; (±)5,6-EpETrE
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5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50=0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2.
Cat. No.: HY-P10735
CAS No.: 181591-59-3
Synonyms: Gastric inhibitory polypeptide(mouse); GIP(1-42) (mouse)
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GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose). GKA50 stimulates insulin release from mouse islets of Langerhans. GKA50 is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca 2+-dependent modulator of insulin secretion. GKA50 shows significant glucose lowering in high fat fed female rats .
Cat. No.: HY-P990254
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Cat. No.: HY-P5396A
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Cat. No.: HY-16673
CAS No.: 857652-30-3
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PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders .
Cat. No.: HY-15671A
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GKA50 quarterhydrate is a potent glucokinase activator (EC50=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca 2+-dependent modulator of insulin secretion. GKA50 quarterhydrate shows significant glucose lowering in high fat fed female rats .
Cat. No.: HY-174559
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Human PAX4 mRNA encodes the human paired box 4 (PAX4) protein, a member of the paired box (PAX) family. PAX4 is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.
Cat. No.: HY-P5396
CAS No.: 152468-44-5
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Cat. No.: HY-139792
CAS No.: 1177460-72-8
Synonyms: SHR117887
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Besigliptin tosylate (SHR117887) is a DPP-4 inhibitor with activity to improve metabolic control and β-cell function. Besigliptin tosylate can effectively reduce serum DPP-4 activity and improve oral glucose tolerance. Besigliptin tosylate significantly reduces fasting blood glucose levels and improves lipid profiles in a diabetic mouse model. The effect of besigliptin tosylate is comparable to that of the known compound vildagliptin (HY-14291) at the same concentration. Besigliptin tosylate increases insulin staining of pancreatic islet cells in chronic administration, indicating improved β-cell function .
Cat. No.: HY-D3174
CAS No.: 2688758-23-6
Cat. No.: HY-P992574
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Anti-Mouse CD226/DNAM-1 Antibody (480.1) is a rat IgG2a κ isotype blocking monoclonal antibody targeting CD226. Anti-Mouse CD226/DNAM-1 Antibody (480.1) competitively blocks the interaction between CD226 and its ligand CD155, inhibiting CD226-mediated costimulatory signaling. Anti-Mouse CD226/DNAM-1 Antibody (480.1) reduces CD4 + and CD8 + effector T cell proliferation and IFN‑γ secretion, and elevates STAT5 phosphorylation levels in regulatory T cells. Anti-Mouse CD226/DNAM-1 Antibody (480.1) attenuates the severity of insulitis in NOD mice, reduces the risk of type 1 diabetes onset, and decreases infiltration of islet-specific IGRP-reactive CD8 + T cells. Anti-Mouse CD226/DNAM-1 Antibody (480.1) can be used for research on CD226-mediated diseases, such as type 1 diabetes .
Cat. No.: HY-P992555
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Anti-Mouse BTLA/CD272 Antibody (6F7) is an anti-BTLA antibody that binds BTLA/CD272 and depletes BTLA + cells. Anti-Mouse BTLA/CD272 Antibody (6F7) increases IL-4, IL-10, IL-2, and IFN-γ expression, and decreases anti-PD-1-enhanced IL-12 (p40/p70). Anti-Mouse BTLA/CD272 Antibody (6F7) delays the onset of spontaneous diabetes in aged but not young female NOD mice, attenuates anti-PD-1-induced diabetes in both age groups, protects prediabetic NOD mice from anti-PD-1-induced insulitis, and reduces pancreatic islet B/helper T cell infiltration. Anti-Mouse BTLA/CD272 Antibody (6F7) can be used for research on type 1 diabetes and insulitis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
