3

3 Cited Publications

Target:

Research Areas:

Trihexyphenidyl hydrochloride is a selective and orally active M₁ muscarinic receptor antagonist with an IC₅₀ of 3.7 nM for rat cerebral cortex M1 muscarinic receptors. Trihexyphenidyl hydrochloride modulates cholinergic activity, countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl hydrochloride improves movement disorder, inhibits McN-A-343 (HY-107648)-induced pressor responses, vagally-induced bradycardia and vasodilatation. Trihexyphenidyl hydrochloride can be used for the research of Parkinson's disease. .

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2

Rimtuzalcap

2 Cited Publications

Cat. No.: HY-109160

CAS No.: 2167246-24-2

Purity: 99.27%

Synonyms: CAD-1883

Target:

Potassium Channel

Research Areas:

Neurological Disease

Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA) .

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1

Taminadenant

1 Cited Publications

Cat. No.: HY-109139

CAS No.: 1337962-47-6

Purity: 99.84%

Synonyms: NIR178; PBF509

Target:

Adenosine Receptor

Research Areas:

Neurological Disease Cancer

Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A_2A receptor (A_2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with K_B values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparkinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab (HY-P9972). Taminadenant reactivate the antitumor immune response .

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1

Basimglurant

1 Cited Publications

Cat. No.: HY-15446

CAS No.: 802906-73-6

Purity: ≥98.0%

Synonyms: RG7090; RO4917523

Target:

mGluR

Research Areas:

Neurological Disease

Basimglurant (RG7090; RO4917523) is a selective, orally active, blood-brain barrier permeable negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5), with a K_i of 1.4 nM (against [ ³H]-ABP688 (HY-110141)) and 35.6 nM (against [ ³H]-MPEP (HY-14609A)). Basimglurant inhibits mGlu5-mediated signaling pathways and receptor constitutive activity, regulates dopamine levels in the nucleus accumbens, exerts anxiolytic, antidepressant-like, analgesic and arousal-promoting effects, and alters δ-wave power during non-rapid eye movement sleep. Basimglurant can be used in research on depression, fragile X syndrome, anxiety disorders, etc .

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1

Azamethiphos

1 Cited Publications

Cat. No.: HY-114899

CAS No.: 35575-96-3

Purity: 96.46%

Target:

Environmental Pollutants Cholinesterase (ChE) Insecticide

Research Areas:

Infection Neurological Disease

Azamethiphos is an acetylcholinesterase inhibitor and insecticide. Azamethiphos covalently binds to acetylcholinesterase via phosphorylation, inhibits its activity, causes acetylcholine to accumulate in cholinergic synapses, triggers uncontrolled excitation of cholinergic sites, induces paralysis and leads to death. Azamethiphos can be used as a bath insecticide in salmonid aquaculture to control sea lice infestations, and it exerts acute toxicity to European lobster larvae, including mortality and movement disorders .

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(+)-Tetrabenazine

Cat. No.: HY-B0590B

CAS No.: 1026016-83-0

Synonyms: (+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine

Target:

Monoamine Transporter

Research Areas:

Cancer

(+)-Tetrabenazine ((+)-TBZ) is the enantiomer of Tetrabenazine (HY-B0590) and is also a Vesicular Monoamine Transporter 2 (VMAT2) inhibitor with a rat K_i of 4.61 nM. (+)-Tetrabenazine inhibits monoamine uptake into granular vesicles of presynaptic neurons. (+)-Tetrabenazine is 3 times more active than (-)-Tetrabenazine. (+)-Tetrabenazine can be used for the research of Huntington's disease and hyperkinetic movement disorders (including chorea) .

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Dihydrotetrabenazine

Cat. No.: HY-141554

CAS No.: 3466-75-9

Purity: 99.23%

Synonyms: DHTBZ

Target:

Monoamine Transporter

Research Areas:

Neurological Disease

Dihydrotetrabenazine (DHTBZ) is the active metabolite of Tetrabenazine (HY-B0590). Dihydrotetrabenazine is the inhibitor for human vesicular monoamine transporter 2 (VMAT2), that reduces monoamine content in presynaptic neurons, and can be used in movement disorder research .

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Tat-βsyn-degron

Cat. No.: HY-P10360

CAS No.: 2816095-52-8

Target:

α-synuclein

Research Areas:

Neurological Disease

Tat-βsyn-degron is an α-synuclein knockdown peptide that effectively degrades α-synuclein protein via the proteasome pathway. Tat-βsyn-degron effectively reduces α-synuclein protein levels in primary rat cortical neuron cultures. In a Parkinson's mouse toxicity model, Tat-βsyn-degron can alleviate parkinsonian toxin-induced neuronal damage and movement disorders .

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Trihexyphenidyl

Cat. No.: HY-B1277A

CAS No.: 144-11-6

Target:

mAChR Cholinesterase (ChE)

Research Areas:

Cardiovascular Disease Neurological Disease

Trihexyphenidyl is a selective and orally active M₁ muscarinic receptor antagonist with an IC₅₀ of 3.7 nM for rat cerebral cortex M1 muscarinic receptors. Trihexyphenidyl modulates cholinergic activity, countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl improves movement disorder, inhibits McN-A-343 (HY-107648)-induced pressor responses, vagally-induced bradycardia and vasodilatation. Trihexyphenidyl can be used for the research of Parkinson's disease. .

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