4328 Results for "

multiple ESKAPEE strains

" in MedChemExpress (MCE) Product Catalog:

Products (4328)

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327

Selisistat

327 Publications Verification

Cat. No.: HY-15452

CAS No.: 49843-98-3

Purity: 99.85%

Synonyms: EX-527

Target:

Sirtuin

Research Areas:

Inflammation/Immunology Cancer

Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC₅₀ of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease .

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286

Bortezomib

286 Cited Publications

Cat. No.: HY-10227

CAS No.: 179324-69-7

Purity: 99.91%

Synonyms: PS-341; LDP-341; NSC 681239

Target:

Proteasome NF-κB Apoptosis Autophagy TREM receptor Ligands for Target Protein for PROTAC

Research Areas:

Cancer

Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

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246

Phosphatase Inhibitor Cocktail Ⅲ (100× in DMSO)

246 Cited Publications

Cat. No.: HY-K0023

Phosphatase Inhibitor Cocktail Ⅲ (100× in DMSO) is a mixture of multiple phosphatase inhibitors that effectively inhibit serine/threonine phosphatases and alkaline phosphatases, and is used to preserve the phosphorylation status of proteins.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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166

Navitoclax

166 Cited Publications

Cat. No.: HY-10087

CAS No.: 923564-51-6

Purity: 99.72%

Synonyms: ABT-263

Target:

Bcl-2 Family

Research Areas:

Cancer

Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-x_L, Bcl-2 and Bcl-w, with a K_i of less than 1 nM .

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Luteolin monohydrate

99 Cited Publications

Cat. No.: HY-W303895

CAS No.: 6113-16-2

Target:

Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite

Research Areas:

Others Cancer

Luteolin (monohydrate) is the monohydrate of Luteolin. Luteolin (Luteoline), a flavonoid, is also a potent Nrf2 inhibitor. Luteolin has anti-inflammatory and anticancer properties, induces apoptosis and cell cycle arrest in multiple human cancer cell lines, including non-small lung cancer cells, and inhibits cell metastasis and angiogenesis .

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