25 Results for "

mutagen

" in MedChemExpress (MCE) Product Catalog:
Products (25)

25 Results for "mutagen" in MCE Product Catalog:

24
N-Nitroso-N-methylurea
N-Nitroso-N-methylurea
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24 Publications Verification
Cat. No.: HY-34758
CAS No.: 684-93-5
Target:  

Environmental Pollutants DNA Alkylator/Crosslinker

Research Areas:  

Cancer

N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane .
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15
Methylnitronitrosoguanidine
Methylnitronitrosoguanidine
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15 Cited Publications
Cat. No.: HY-128612
CAS No.: 70-25-7
Purity:  99.96%
Synonyms: MNNG
Target:  

DNA Alkylator/Crosslinker

Research Areas:  

Cancer

Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. Methylnitronitrosoguanidine can as a carcinogen and mutagen . 50% water content, specifications are based on dry weight.
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4
Acridin-9-amine hydrochloride hydrate
Acridin-9-amine hydrochloride hydrate
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4 Cited Publications
Cat. No.: HY-W011950
CAS No.: 52417-22-8
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

Acridin-9-amine (9-Aminoacridine) hydrochloride hydrate is a mutagen and DNA modifier. Acridin-9-amine hydrochloride hydrate induces mutagenic lesions during DNA replication .
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N-Butyl-N-(4-hydroxybutyl)nitrosamine
N-Butyl-N-(4-hydroxybutyl)nitrosamine
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Cat. No.: HY-W755252
CAS No.: 3817-11-6
Synonyms: BBN
Target:  

DNA Alkylator/Crosslinker

Research Areas:  

Cancer

N-Butyl-N-(4-hydroxybutyl)nitrosamine is a potent mutagen that can cause high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. N-Butyl-N-(4-hydroxybutyl)nitrosamine is used to induce bladder cancer in rodents .
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α-Hexylcinnamaldehyde
α-Hexylcinnamaldehyde
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Cat. No.: HY-W014118
CAS No.: 101-86-0
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer

Target:  

Environmental Pollutants

α-Hexylcinnamaldehyde is an O-acetyltransferase (OAT) inhibitor. α-Hexylcinnamaldehyde inhibits OAT-mediated bioactivation of nitroarene mutagens, exerts antimutagenic activity through demutagenic and bioantimutagenic mechanisms, and interferes with ATP-binding cassette (ABC) transporter function to reduce substrate efflux. α-Hexylcinnamaldehyde alters membrane permeability, fluidizes phospholipid membranes, exerts antioxidant effects, and enhances the antiproliferative effect of Doxorubicin on human cancer cells. α-Hexylcinnamaldehyde can be used in the research of colorectal adenocarcinoma, T-cell leukemia, and multidrug-resistant cancers .
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Dihydralazine sulfate
Dihydralazine sulfate
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Cat. No.: HY-N7065
CAS No.: 7327-87-9
Target:  

Drug Derivative

Research Areas:  

Cardiovascular Disease Neurological Disease

Dihydralazine sulfate is an antihypertensive hydrazine derivative and also a low-potency genotoxic agent. Dihydralazine sulfate is a direct-acting mutagen with a mixed gene mutation mechanism, which induces DNA fragmentation in the lung, kidney and spleen of mice, and induces sister chromatid exchange in mouse bone marrow cells. Dihydralazine sulfate specifically kills DNA repair-deficient bacteria. Dihydralazine sulfate is a vasodilator and antihypertensive agent that reduces systemic vascular resistance, increases cardiac output and heart rate, thereby lowering blood pressure. Dihydralazine sulfate can be used in research related to hypertension and severe early-onset preeclampsia .
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8-Oxo-dGTP
8-Oxo-dGTP
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Cat. No.: HY-112817
CAS No.: 139307-94-1
Synonyms: 8-Oxo-Deoxyguanosine triphosphate
Target:  

Apoptosis

Research Areas:  

Cardiovascular Disease Neurological Disease Cancer

8-Oxo-dGTP (8-Oxo-Deoxyguanosine triphosphate) is an oxidized guanine nucleotide formed by ROS-mediated oxidative modification of dGTP, and it also serves as a key substrate for 8-oxo-dGTP pyrophosphohydrolases (such as hMTH1 and E. coli MutT). 8-Oxo-dGTP acts as a DNA mutagen, inserts into nascent DNA and pairs with adenine and cytosine, inducing A:T to C:G transversion mutations. Furthermore, 8-Oxo-dGTP causes oxidative DNA base modification, strand breakage and S-phase arrest, and ultimately triggers AIF-mediated apoptosis and promotes spontaneous carcinogenesis in mth1-deficient mice. Accumulation of 8-Oxo-dGTP in cells induces genomic instability, but it exhibits a tumor-suppressive effect that reduces tumor incidence in mouse models instead. 8-Oxo-dGTP is widely used in studies related to spontaneous carcinogenesis, Parkinson's disease, Alzheimer's disease, heart failure and tumor mechanisms .
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5-Formyl-dCTP lithium
5-Formyl-dCTP lithium
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Cat. No.: HY-160596
CAS No.: 2409156-19-8
Synonyms: 5-Formyl-deoxycytidine lithium
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

5-Formyl-dCTP (5-Formyl-deoxycytidine) lithium is a DCTPP1 substrate. 5-Formyl-dCTP lithium acts as a mutagen/epigenetic disruptor via DNA polymerase incorporation, mutagenic mispairings, and disturbed epigenetic programming. 5-Formyl-dCTP lithium can be used for research on genotoxicity .
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4-OHE
4-OHE
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Cat. No.: HY-N12851
CAS No.: 2492-43-5
Synonyms: (E)-4-Oxo-2-hexenal
Category:  

Animals Ketones, Aldehydes, Acids

Target:  

Bacterial Apoptosis

4-OHE ((E)-4-Oxo-2-hexenal) is a mutagen formed by omega-3 lipid peroxidation. 4-OHE reacts with deoxyguanosine, deoxycytidine and 5-methyldeoxycytidine to form covalent adducts. 4-OHE induces apoptosis and exhibits genotoxicity. 4-OHE inhibits the growth of Gram-positive and Gram-negative bacteria, which correlates with its electrophilic reactivity towards nucleophilic biomolecules. 4-OHE is a chemical defense component of Dolycoris baccarum (sloe bug), and acts as a deterrent and toxin against insect predators .
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Licoisoflavone B
Licoisoflavone B
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Cat. No.: HY-N3388
CAS No.: 66056-30-2
Category:  

Flavonoids Metabolic Disease Phenols Polyphenols 500 - Internal Server Error | MedChemExpress

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