country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

27 Results for "

mutation specificity

" in MedChemExpress (MCE) Product Catalog:

Products (27)

Sort by :

Categories

By Targets

Products

SK-575

5 Cited Publications

Cat. No.: HY-139156

CAS No.: 2523016-96-6

Purity: 99.86%

Target:

PROTACs PARP

Research Areas:

Cancer

SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1, with an IC₅₀ of 2.30 nM. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

Bexobrutideg

4 Cited Publications

Cat. No.: HY-153321

CAS No.: 2649400-34-8

Purity: 98.67%

Synonyms: NX-5948; BTK-IN-24

Target:

PROTACs Btk

Research Areas:

Inflammation/Immunology

Bexobrutideg (NX-5948) is an orally active chimeric targeting molecule (CTM) that induces specific BTK protein degradation by the cereblon E3 ligase (CRBN) complex without degradation of other cereblon neo-substrates. Bexobrutideg mediates potent anti-inflammatory activity via BTK degradation with resultant inhibition of B cell activation. Bexobrutideg exhibits potent tumor growth inhibition in TMD8 xenograft models that contain either wild-type BTK or BTKi-resistant mutations. Bexobrutideg is efficacious in a mouse collageninduced arthritis (CIA) model. Bexobrutideg can cross the blood brain barrier (BBB). Bexobrutideg is a PROTAC composed of the ligand for target protein, a linker, and a cereblon E3 ligase (CRBN) complex (Red: BTK ligand (HY-170324); Blue: CRBN ligand (HY-171893); Black: linker) .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

Zinpyr-1

4 Cited Publications

Cat. No.: HY-D0155

CAS No.: 288574-78-7

Zinpyr-1 is a zinc-responsive fluorescent indicator and a membrane-permeable metal-binding probe. Zinpyr-1 forms a complex with Mn ²⁺ ions and generates a fluorescence turn-on signal. Zinpyr-1 binds to free zinc ions in serum, enabling quantitative detection of free zinc concentration. Zinpyr-1 produces fluorescence signals reflecting the relative zinc concentration in plant root cells, localizes to specific layers of plant root cells, and can be used to support analyses related to plant zinc transporter mutations and homeostasis .

Compare