434

PD98059

434 Publications Verification

Cat. No.: HY-12028

CAS No.: 167869-21-8

Purity: 98.89%

Target:

MEK ERK Aryl Hydrocarbon Receptor Autophagy

Research Areas:

Cancer

PD98059 is a potent and selective MEK inhibitor with an IC₅₀ of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC₅₀ of 2-7 µM) and MEK2 (IC₅₀ of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC₅₀ of 4 μM) and AHR transformation (IC₅₀ of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy .

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68

Poly (I:C):Kanamycin (1:1) sodium

68 Cited Publications

Cat. No.: HY-135748A

Target:

RIG-I-like receptor (RLR) Toll-like Receptor (TLR) Apoptosis

Research Areas:

Infection Cancer

Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia .

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59

Bedaquiline fumarate

59 Cited Publications

Cat. No.: HY-14881A

CAS No.: 845533-86-0

Purity: 99.97%

Synonyms: R403323; TMC207 fumarate; R207910 fumarate

Target:

Bacterial Antibiotic

Research Areas:

Infection

Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.

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59

Bedaquiline

59 Cited Publications

Cat. No.: HY-14881

CAS No.: 843663-66-1

Purity: 99.98%

Synonyms: TMC207; R207910

Target:

Bacterial Antibiotic

Research Areas:

Infection

Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

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18

Cordycepin

18 Cited Publications

Cat. No.: HY-N0262

CAS No.: 73-03-0

Synonyms: 3'-Deoxyadenosine

Category:

Infection Natural Products Microorganisms Disease Research Fields Inflammation/Immunology Cancer

Target:

TNF Receptor MMP Bacterial Autophagy Antibiotic

Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .

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9

Telacebec

9 Cited Publications

Cat. No.: HY-101040

CAS No.: 1334719-95-7

Purity: 99.40%

Synonyms: Q203; IAP6

Target:

Bacterial Antibiotic

Research Areas:

Infection

Telacebec (Q203) is a midazopyridine amide compound. Telacebec is active against Mycobacterium tuberculosis H37Rv with an MIC₅₀ of 2.7 nM in culture broth medium.

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5

Ganfeborole hydrochloride

5 Cited Publications

Cat. No.: HY-107775

CAS No.: 2131798-13-3

Purity: 99.97%

Synonyms: GSK656; GSK3036656; GSK070

Target:

Bacterial

Research Areas:

Infection

Ganfeborole hydrochloride (GSK656) is a potent antitubercular agent, acting as an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), with an IC₅₀ of 0.2 μM.

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