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32 Results for "

myogenic

" in MedChemExpress (MCE) Product Catalog:

Products (32)

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Dimethyl succinate

3 Cited Publications

Cat. No.: HY-Y0808

CAS No.: 106-65-0

Dimethyl succinate is an orally active cell permeable succinate analogue. Dimethyl succinate can disrupt the TCA cycle by elevating intracellular succinate levels, leading to reduced protein synthesis and impairs myogenic differentiation. Dimethyl succinate can induce apoptosis. Dimethyl succinate can decrease maximal cellular respiration and reserve capacity. Dimethyl succinate can rescue synapse loss in AD. Dimethyl succinate can be used for the researches of metabolic and neurological disease ^[1][2].

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Benzamil hydrochloride

2 Cited Publications

Cat. No.: HY-B1546A

CAS No.: 161804-20-2

Synonyms: Benzylamiloride hydrochloride

Target:

Na+/Ca2+ Exchanger Sodium Channel

Research Areas:

Neurological Disease

Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca ²⁺-activated currents, with an IC₅₀ of 1.1 μM .

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Glycocyamine

1 Cited Publications

Cat. No.: HY-W021448

CAS No.: 352-97-6

Synonyms: Guanidinoacetic acid

Category:

Other disease Ketones, Aldehydes, Acids Other Diseases Disease markers Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Glycocyamine (Guanidinoacetic acid) is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming .

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PFI-90

1 Cited Publications

Cat. No.: HY-139348

CAS No.: 53995-62-3

Purity: 99.86%

Target:

Histone Demethylase Apoptosis

Research Areas:

Cancer

PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).

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CX-5011

Cat. No.: HY-50733A

CAS No.: 1333382-30-1

Target:

Casein Kinase

Research Areas:

Neurological Disease Cancer

CX-5011 is an ATP-competitive, selective CK2 inhibitor with an IC₅₀ of 0.97 nM for nCK2. CX-5011 reduces Bin1, CKB, Tubb3, and Pxn levels . CX-5011 impairs myogenic differentiation, myotube formation, muscle markers, myofiber growth, and zebrafish muscle development/locomotion. CX-5011 can be used for breast cancer research .

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