316 Results for "

near

" in MedChemExpress (MCE) Product Catalog:
Products (316)

316 Results for "near" in MCE Product Catalog:

19
19 Publications Verification
Cat. No.: HY-18936
CAS No.: 349438-38-6
Research Areas:  

Cancer

Alda-1 is a potent and selective ALDH2 agonist, which activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2.
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12
12 Cited Publications
Cat. No.: HY-19730
CAS No.: 1353550-13-6
Synonyms: HM61713; BI 1482694
Target:  

EGFR

Research Areas:  

Cancer

Olmutinib (HM61713; BI-1482694) is an orally active and irreversible third EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain. Olmutinib is used for NSCLC .
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8
8 Cited Publications
Cat. No.: HY-12654
CAS No.: 1154028-82-6
Purity:  98.58%
Synonyms: BAY 85-3934
Research Areas:  

Cardiovascular Disease

Molidustat (BAY 85-3934) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat can be utilized in the research of renal anemia .
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7
7 Cited Publications
Cat. No.: HY-112641A
CAS No.: 2558205-28-8
Purity:  99.92%
AkaLumine hydrochloride is a D-luciferin (HY-12591A) analogue with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. AkaLumine hydrochloride emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc. AkaLumine hydrochloride has high tissue-penetration and increases detection sensitivity from deep-tissue targets .
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7
7 Cited Publications
Cat. No.: HY-D1063
CAS No.: 207399-07-3
IR-780 is a near-infrared fluorescent probe for in vivo imaging of tumor cells. IR-780 is transported into tumor cells via OATPs and ABCB10, with uptake dependent on glycolytic activity and plasma membrane potential. IR-780 preferentially accumulates in tumor cell mitochondria, including those of drug-resistant cancer cells, without chemical conjugation. IR-780 generates reactive oxygen species (ROS), induces hyperthermia and apoptosis, inhibits tumor growth and recurrence, and modulates HSP70 expression upon ultrasound or 808 nm laser exposure. IR-780 acts as a sonosensitizer, photodynamic and photothermal agent, and drug delivery carrier, with low acute imaging-dose toxicity and rapid vital organ clearance. IR-780 can be used for the research of cancer, such as breast cancer, lung cancer, and non-small cell lung cancer (NSCLC) .
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4
4 Cited Publications
Cat. No.: HY-111653
CAS No.: 1247879-16-8
Purity:  99.72%
CycLuc1 is a blood-brain barrier permeable luciferase substrate that displays near-infrared (NIR) emission with a peak luminescence wavelength of 599 nm. CycLuc1 can be used for in vivo bioluminescence imaging .
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4
4 Cited Publications
Cat. No.: HY-D1068
CAS No.: 1564286-24-3
Synonyms: DBCO-Sulfo-Cy5
Cy5-DBCO (DBCO-Sulfo-Cy5) is a near-infrared (NIR)red fluorescent dye with λabsand λem of 646nm and 670 nm, respectively. Cy5-DBCO (DBCO-Sulfo-Cy5) is not suitable for staining intracellular components of permeabilezed cell, it may exhibits a high background. Cy5-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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3
3 Cited Publications
Cat. No.: HY-B1157
CAS No.: 3902-71-4
Synonyms: Trisoralen; Trioxysalen; TMP
Research Areas:  

Inflammation/Immunology

Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation .
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2
2 Cited Publications
Cat. No.: HY-136886
CAS No.: 172616-80-7
Purity:  96.36%
Synonyms: New Indocyanine Green
IR-820 (New Indocyanine Green) is an infrared blood pool contrast agent. IR-820 also is normally used as a laser and near-infrared dye to detect and quantify diseased tissue in live animals .
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2
2 Cited Publications
Cat. No.: HY-139579
CAS No.: 1628423-76-6
Purity:  98.59%
Synonyms: OTL 38
Pafolacianine (OTL 38) is a fluorescent imaging agent made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine excites at 774 to 775 nm and emits at 794 to 796 nm .
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2
2 Cited Publications
Cat. No.: HY-D1744
CAS No.: 2143933-81-5
ICG Maleimide is thiol reactive near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging (Ex/Em = 789/813 nm).
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2
2 Cited Publications
Cat. No.: HY-W088089
CAS No.: 181934-09-8
ICG-carboxylic acid is near-infrared (NIR) fluorescent probe. ICG is a fluorescent dye used in medical diagnostics. ICG has absorption peaking at 800 nm and can absorb the near IR laser energy and release heat in the dyed tissue (Ex/Em = 785/810 nm) .
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2
2 Cited Publications
Cat. No.: HY-133884
CAS No.: 1686147-55-6
Purity:  99.91%
Target:  

Fluorescent Dye

Research Areas:  

Cancer

ICG amine, as a near-infrared fluorescent probe, binds to amino acid residues without condensing agents. ICG is a tricarbocyanine dye .
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2
2 Cited Publications
Cat. No.: HY-157508
CAS No.: 3061959-30-3
Purity:  99.94%
Target:  

p97

Research Areas:  

Others

VCP Activator 1 is a VCP activator that dose-dependently stimulates VCP ATPase activity. VCP Activator 1 binds an allosteric pocket near the C-terminus. In addition, VCP Activator 1 binding site can also be occupied by a phenylalanine residue in the VCP C-terminal tail .
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1
1 Cited Publications
Cat. No.: HY-D1041
CAS No.: 1622335-40-3
Synonyms: ICG-OSu
ICG NHS ester (ICG-OSu) is a near-infrared fluorescent agent ICG derivative. ICG NHS ester is amine-reactive and has been widely used to design in vivo imaging probes .
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1
1 Cited Publications
Cat. No.: HY-D1464
CAS No.: 1622250-38-7
CH1055 is a near-infrared II (NIR-II) fluorescent dye that can be used as a fluorescent probe for in vivo imaging. CH1055 can be conjugated with antibodies or ligands for specific imaging (for example the tumor imaging) .
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1
1 Cited Publications
Cat. No.: HY-D1449
CAS No.: 155614-01-0
Target:  

Fluorescent Dye

Research Areas:  

Others

IR-1061 is a near infrared fluorescent organic dye for in vivo bimodal imaging .
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1
1 Cited Publications
Cat. No.: HY-D1719
CAS No.: 95837-47-1
Target:  

Fluorescent Dye

Research Areas:  

Others

Cypate, a cyanine dye, is a near infrared (NIR) fluorescent probe for in vivo tumor imaging .
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1
1 Cited Publications
Cat. No.: HY-137296
CAS No.: 4386-25-8
Purity:  99.79%
Lumogallion is a highly sensitive fluorescent reagent for the detection of aluminum, gallium and other metals. Lumogallion has an excitation wavelength of 490 nm and an emission spectrum in the range of 520 nm to 650 nm, with a peak near 580 nm .
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1
1 Cited Publications
Cat. No.: HY-D1719A
Target:  

Fluorescent Dye

Research Areas:  

Cancer

Cypate is a near-infrared fluorescent dye that belongs to the family of photosensitizers. Cypate has high photostability and optical properties, and is often used in near-infrared optical imaging, as well as optical imaging, tumor marking, and drug delivery. In addition, Cypate is also used as a molecular probe and combined with targeting molecules (such as CBT or small interfering RNA) to achieve efficient detection and imaging of specific cells or tissues .
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