2 Results for "

negative chronotropic agent

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "negative chronotropic agent" in MCE Product Catalog:

Phytolaccagenin
Phytolaccagenin
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Cat. No.: HY-N1433
CAS No.: 1802-12-6
Category:  

Phytolaccaceae Extract Triterpenes Plant Terpenoids Disease Research Fields Inflammation/Immunology Phytolacca acinosa Roxb. Extract

Target:  

Fungal mAChR Adrenergic Receptor Calcium Channel

Phytolaccagenin is a triterpenoid saponin aglycone, Antifungal agent, vasodilator, antihypertensive agent, and anti-inflammatory agent. Phytolaccagenin activates vascular and cardiac Muscarinic receptors, blocks cardiac β-adrenergic receptors, and inhibits voltage-dependent calcium channels in blood vessels. Phytolaccagenin inhibits the growth of Candida albicans and Cryptococcus neoformans. Phytolaccagenin induces vasodilation, produces negative inotropic and negative chronotropic effects, reduces mean arterial pressure, and inhibits LPS-induced inflammation. Phytolaccagenin exhibits enhanced antihypertensive effects in high salt-induced hypertensive rats. Phytolaccagenin can be used in the research of candidiasis, cryptococcosis, hypertension, and inflammation-related diseases .
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Tabernanthine
Tabernanthine
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Cat. No.: HY-N8421
CAS No.: 83-94-3
Category:  

Alkaloids Plant Tabernanthe iboga Baill. Extract Indole Alkaloids Apocynaceae Extract

Target:  

Potassium Channel

Tabernanthine is a negative chronotropic and negative inotropic agent that selectively acts on sinoatrial node receptors, regulating heart rhythm and myocardial contractility. Tabernanthine exhibits atropine resistance and direct non-cholinergic binding properties, acting directly on the sinoatrial node rather than relying on vagal nerve or cholinergic pathways to exert its key activity of slowing heart rate and weakening myocardial contractility. Tabernanthine is useful in cardiovascular pharmacology research, particularly in the areas of sinoatrial node function regulation, mechanisms related to bradycardia, and studies of cardiac receptor subtype differences .
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