148

148 Publications Verification

Synonyms: β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol

Category:

Endocrine diseases Endogenous metabolite Monophenols Sunscreen Disease markers Phenols Cosmetic Research Disease Research Fields Cancer Steroids

Target:

Estrogen Receptor/ERR Endogenous Metabolite Bacterial

Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

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148

Estradiol hemihydrate

148 Publications Verification

Cat. No.: HY-B0141C

CAS No.: 35380-71-3

Synonyms: β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate

Category:

Endogenous metabolite Steroids

Target:

Estrogen Receptor/ERR Endogenous Metabolite Bacterial

Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

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17

DMH-1

17 Cited Publications

Cat. No.: HY-12273

CAS No.: 1206711-16-1

Purity: 99.93%

Target:

TGF-β Receptor Organoid Microtubule/Tubulin

Research Areas:

Cardiovascular Disease Neurological Disease

DMH-1 is a selective BMP inhibitor. DMH-1 upregulates the expression of SOX1. DMH-1 increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons .

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14

L-Cysteine

14 Cited Publications

Cat. No.: HY-Y0337

CAS No.: 52-90-4

Synonyms: Cysteine

Category:

Human Gut Microbiota Metabolites Microorganisms Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:

Environmental Pollutants Endogenous Metabolite

L-Cysteine (Cysteine) is an orally active conditionally essential amino acid with hypoglycemic effects, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans. L-Cysteine can be used as an anorectic agent .

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12

ISX-9

12 Cited Publications

Cat. No.: HY-12323

CAS No.: 832115-62-5

Purity: 99.19%

Synonyms: Isoxazole 9

Target:

Calcium Channel

Research Areas:

Neurological Disease

ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca ²⁺ influx through both voltage-gated Ca ²⁺ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) .

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3

Surfen dihydrochloride

3 Cited Publications

Cat. No.: HY-122704A

CAS No.: 5424-37-3

Synonyms: Aminoquinuride dihydrochloride

Target:

FGFR HSV Tau Protein

Research Areas:

Infection Neurological Disease Inflammation/Immunology

Surfen dihydrochloride is a potent heparan sulfate antagonist. Surfen inhibits FGF2 binding and signal transduction. Surfen binds to glycosaminoglycans and reduces tau hyperphosphorylation. Surfen dihydrochloride inhibits the activity of recombinant uronyl 2-O-sulfotransferase with an IC₅₀ of approximately 2 μM. Surfen dihydrochloride inhibits HSV-1 viral infection. Surfen dihydrochloride inhibits neural differentiation, delays remyelination, and alleviates EAE .

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2

Estradiol (Standard)

2 Cited Publications

Cat. No.: HY-B0141R

CAS No.: 50-28-2

Synonyms: β-Estradiol (Standard); E2 (Standard); 17β-Estradiol (Standard); 17β-Oestradiol (Standard)

Category:

Sunscreen Disease markers Endocrine diseases Phenols Cosmetic Research Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Reference Standards Estrogen Receptor/ERR Endogenous Metabolite Bacterial

Estradiol (Standard) is the analytical standard of Estradiol. This product is intended for research and analytical applications. Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

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1

SR11237

1 Cited Publications

Cat. No.: HY-107413

CAS No.: 146670-40-8

Purity: 99.79%

Synonyms: BMS-649

Target:

RAR/RXR Tyrosine Hydroxylase

Research Areas:

Cancer

SR11237 (BMS-649) GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease .

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1

Neuropathiazol

1 Cited Publications

Cat. No.: HY-10591

CAS No.: 880090-88-0

Purity: 98.73%

Target:

TGF-β Receptor

Research Areas:

Neurological Disease

Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells .

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1

Musk ketone

1 Cited Publications

Cat. No.: HY-N2045

CAS No.: 81-14-1

Target:

Environmental Pollutants Apoptosis Akt Cytochrome P450 PI3K

Research Areas:

Neurological Disease

Musk ketone is a widely used artificial fragrance. Musk ketone is also a cytochrome P450 enzyme inducer. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis .

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Docosahexaenoic acid (Standard)

Cat. No.: HY-B2167R

CAS No.: 6217-54-5

Synonyms: DHA (Standard); Cervonic acid (Standard)

Category:

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Cardiovascular System Disorder

Target:

Reference Standards Endogenous Metabolite

Docosahexaenoic acid (Standard) is the analytical standard of Docosahexaenoic acid. This product is intended for research and analytical applications. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk. In Vitro: Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. The inclusion of plentiful DHA in the diet improves learning ability and memory . DHA is an essential requirement in every step of brain development like neural cell proliferation, migration, differentiation, synaptogenesis. The multiple double bonds and unique structure allow DHA to impart special membrane characteristics for effective cell signaling. Many development disorders like dyslexia, autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia etc. are causally related to decreased level of DHA . DHA is a potent RXR ligand inducing robust RXR activation already at low micro molar concentrations. The EC₅₀ for RXRα activation by DHA is about 5-10 μM fatty acid . In Vivo: Docosahexaenoic acid administration over 10 weeks significantly reduces the number of reference memory errors, without affecting the number of working memory errors, and significantly increases the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex . DHA treatment exerts neuroprotective actions on an experimental mouse model of PD. There is a decrease tendency in brain lipid oxidation of MPTP mice but it does not significantly .

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