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4 Results for "

non-addictive

" in MedChemExpress (MCE) Product Catalog:

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AT-121

Cat. No.: HY-112692

CAS No.: 2099681-31-7

Purity: ≥96.0%

Target:

Opioid Receptor

Research Areas:

Neurological Disease

AT-121 is a bifunctional nociception and mu opioid receptor agonist, with K_is of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects .

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AT-121 hydrochloride

Cat. No.: HY-112692A

CAS No.: 2099681-71-5

Target:

Opioid Receptor

Research Areas:

Neurological Disease

AT-121 hydrochloride is a bifunctional nociception and mu opioid receptor agonist, with K_is of 3.67 and 16.49 nM, respectively. AT-121 hydrochloride is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects .

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PL265

Cat. No.: HY-115500

CAS No.: 1206514-50-2

Target:

Endogenous Metabolite Leukotriene Receptor Opioid Receptor

Research Areas:

Neurological Disease Inflammation/Immunology

PL265 is an orally active dual enkephalinase inhibitor. PL265 is a prodrug of PL254, which can simultaneously and efficiently inhibit neutral endopeptidase (Neprilysin) and Aminopeptidase N. PL265 can effectively protect and significantly increase the local concentration of enkephalins (such as Met-Enkephalin and Leu-Enkephalin) released by cells at the pain or inflammation sites, thereby activating μ and δ opioid receptors to produce a potent analgesic effect. PL254 can also inhibit leukotriene A4 hydrolase (LTA4H), which may contribute to its additional anti-inflammatory effect by reducing the production of pro-inflammatory mediator leukotriene B4 (LTB4). PL265 can be used in non-addictive chronic pain research .

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