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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
nonimmunosuppressive
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "nonimmunosuppressive" in MCE Product Catalog:
2
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Research Areas:
GPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke .
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1 Cited Publications
Cat. No.: HY-117720A
Research Areas:
OSU-2S TFA is a non-immunosuppressive derivative of Fingolimod hydrochloride (FTY720) (HY-12005). It is an orally active, blood-brain barrier-permeable allosteric activator of PP2A that also activates PKCδ; it restores PP2A activity by displacing the inhibitory protein SET, thereby inducing ROS-PKCδ-caspase-3-dependent apoptosis, c-Myc degradation, cell cycle arrest, and differentiation. OSU-2S TFA is used in research on diseases such as leukemia, liver cancer, lymphoma, and lung cancer .
Cat. No.: HY-106345
CAS No.: 892494-07-4
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ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12 .
Cat. No.: HY-117720
CAS No.: 1351056-65-9
Research Areas:
OSU-2S is a non-immunosuppressive derivative of Fingolimod hydrochloride (FTY720) (HY-12005). It is an orally active, blood-brain barrier-permeable allosteric activator of PP2A that also activates PKCδ; it restores PP2A activity by displacing the inhibitory protein SET, thereby inducing ROS-PKCδ-caspase-3-dependent apoptosis, c-Myc degradation, cell cycle arrest, and differentiation. OSU-2S is used in research on diseases such as leukemia, liver cancer, lymphoma, and lung cancer .
Cat. No.: HY-P3351
CAS No.: 935735-70-9
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Cat. No.: HY-128924
CAS No.: 1589093-01-5
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NIM258 is a potent nonimmunosuppressive cyclophilin inhibitor (cyclophilin A Kd = 1.2 nM) with anti-HCV activity (EC50 = 40 nM). NIM258 can be used for HCV infection research .
Cat. No.: HY-P1360
CAS No.: 1038781-13-3
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Cat. No.: HY-W746425
CAS No.: 500733-49-3
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Rapamycin dialdehyde is a non-immunosuppressive macrolide dialdehyde that promotes neuronal regeneration and functional recovery by inducing neurite outgrowth, and inhibits solid tumor cell growth and hyperproliferative vascular diseases. Rapamycin dialdehyde is used in the research of neurodegenerative diseases and cancer .
Cat. No.: HY-179354
CAS No.: 292606-90-7
AP21998 is a non-immunosuppressive derivative of Rapamycin (HY-10219) and an inducer of exocytosis. By binding to mutant FKBP (F36M), AP21998 dissociates fusion protein aggregates in the endoplasmic reticulum into monomers, which then enter the Golgi apparatus to be cleaved by furin protease, ultimately releasing the polypeptide. AP21998 can be used in cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
