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10 Results for "

nonmetabolizable

" in MedChemExpress (MCE) Product Catalog:

Products (10)

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Thiodigalactoside

5 Cited Publications

Cat. No.: HY-130208

CAS No.: 51555-87-4

Purity: 99.97%

Synonyms: TDG

Target:

Galectin

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with K_d values of 24 μM, 49 μM for GAL1 and GAL3, respectively . Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats .

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5'-Deoxyadenosine

3 Cited Publications

Cat. No.: HY-113291

CAS No.: 4754-39-6

Purity: 99.92%

Category:

Human Gut Microbiota Metabolites Natural Products Microorganisms Other Diseases Endogenous metabolite Disease Research Fields

Target:

Nucleoside Antimetabolite/Analog Phosphorylase

5'-Deoxyadenosine is a 5'-methylthioadenosine phosphorylase substrate and deoxyadenosine. 5'-Deoxyadenosine serves as a non-metabolizable substrate for nucleoside transport assays only in cells lacking 5'-methylthioadenosine phosphorylase .

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Eicosatetraynoic acid

Cat. No.: HY-124108

CAS No.: 1191-85-1

Purity: ≥99.0%

Synonyms: ETYA

Target:

COX Lipoxygenase Orthopoxvirus Potassium Channel DNA/RNA Synthesis Drug Derivative

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Eicosatetraynoic acid (ETYA) is a non-metabolizable analog of Arachidonic acid (HY-109590) and also an inhibitor of the lipoxygenase (LOX)/cyclooxygenase (COX) pathway (ID₅₀= 8 μM and 4 μM). Eicosatetraynoic acid acts as a suicide substrate to inhibit the production of inflammatory mediators such as leukotrienes and prostaglandins. Eicosatetraynoic acid acts directly on cell membranes and membrane proteins to exert a wide range of effects, including blocking potassium channels, increasing cell membrane fluidity, elevating intracellular calcium levels, inhibiting DNA synthesis in tumor cells, inducing differentiation of certain cells, and specifically inhibiting the assembly and replication of orthopoxviruses. Eicosatetraynoic acid alleviates acute lung injury induced by chemicals such as phosgene .

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