66 Results for "

nonspecific binding

" in MedChemExpress (MCE) Product Catalog:
Products (66)

66 Results for "nonspecific binding" in MCE Product Catalog:

21
21 Publications Verification
Cat. No.: HY-D1421
CAS No.: 257277-27-3
Target:  

Fluorescent Dye

Research Areas:  

Others

PKH67 is a fluorescent cell binding dye with green fluorescence. PKH67 can stain the cell membrane and the Ex/Em is 490/502 nm. PKH67 is often used in combination with the non-specific red fluorescent dye PKH26 (Ex/Em=551/567 nm) to label cells, detect cell proliferation in vitro, and trace cells in vitro and in vivo .
loading...
    loading...
9
9 Cited Publications
Cat. No.: HY-P99977

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Mouse IgG1 kappa, Isotype Control is a negative control reagent/isotype control for mouse-derived IgG1κ antibodies. Mouse IgG1 kappa, Isotype Control, by maintaining the same immunoglobulin structure (including isotype, light chain, etc.) as the specific mouse IgG1κ subtype primary antibody, eliminates false positive signals caused by non-specific binding in immunological experiments, thus playing a core role in verifying the specificity of the experiment. Mouse IgG1 kappa, Isotype Control can be applied to immunolocalization experiments in the field of cell biology, such as immunofluorescence staining and immunohistochemistry, assisting in research on protein subcellular localization and cell structure analysis, ensuring the reliability of experimental results .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P990682

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Rat IgG2b kappa, Isotype Control is a rat IgG2b κ antibody isotype control. Rat IgG2b kappa, Isotype Control can be used as a negative control to exclude or reduce false positive results caused by nonspecific binding .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-D0846
CAS No.: 1609-47-8
Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-NP0182
Synonyms: PNA (Biotinylated)
Target:  

Fluorescent Dye

Research Areas:  

Cancer

Peanut Agglutinin (PNA) Biotinylated is a biotinylated lectin that specifically recognizes and binds to the Galβ1-3GalNAc sequence, thereby targeting SPESP1 and TF blood group antigens. As an acrosome-specific marker, Peanut Agglutinin Biotinylated stains mouse spermatocytes and sperm acrosomes with high specificity, and this binding depends not only on SPESP1 but also recognizes other testicular acrosomal glycoproteins. Peanut Agglutinin Biotinylated accurately identifies TF antigens in Reed-Sternberg cells, histiocytosis X cells, and esophageal squamous cell carcinoma, without cross-reacting with non-specific cells. Peanut Agglutinin Biotinylated maintains staining stability in both B-5 and formalin fixatives, and serves as an important tool for the study of Hodgkin's disease, histiocytosis X, and various malignant tumors .
loading...
    loading...
Cat. No.: HY-12489
CAS No.: 6226-79-5
Purity:  ≥98.0%
Synonyms: Acid Red 112
Ponceau S (Acid Red 112) is a non-specific protein dye commonly used as a stain for Western blot. Ponceau S is used in an acidic aqueous solution that is compatible with antibody-antigen binding and dyes the proteins on the membrane red .
loading...
    loading...
Cat. No.: HY-D1872
CAS No.: 956579-01-4
800CW NHS ester is a near-infrared fluorescent dye active ester that can conjugate with amine-containing small molecules, antibodies, peptides, and other substances to form fluorescent conjugates. 800CW NHS ester exhibits high fluorescence quantum yield and low non-specific binding properties. 800CW NHS ester can be used in biomedical research such as microbial infection imaging, tumor imaging, and biochemical detection .
loading...
    loading...
Cat. No.: HY-P991155
CAS No.: 2988886-91-3
Synonyms: JNJ-79635322; JNJ-5322

Target:  

CD3 TNF Receptor

Research Areas:  

Cancer

Ramantamig (JNJ-79635322) is a humanized monoclonal antibody targeting human CD3ε, GPRC5D, and TNFRSF17 (BCMA). Ramantamig binds to BCMA and GPRC5D on multiple myeloma cells, binds to CD3ε on T cells, forms immunological synapses, and enables T-cell-mediated cytotoxicity. Ramantamig activates T cells concomitantly with inducing myeloma cell cytotoxicity, with no nonspecific T-cell activation in the absence of target myeloma cells. Ramantamig carries mutations to reduce interaction with Fc receptors and disrupt protein A binding of monomeric and homodimerized chains. Ramantamig can be used for the research of multiple myeloma .
loading...
    loading...
Cat. No.: HY-20167A
CAS No.: 32677-01-3
Target:  

Neurokinin Receptor

Research Areas:  

Cancer

H-Glu(OtBu)-OtBu hydrochloride is a key intermediate that can be used to synthesize prostate-specific membrane antigen (PSMA) targeting probes. H-Glu(OtBu)-OtBu hydrochloride can reduce nonspecific background binding through negatively charged linkers, improve tumor/background contrast, and can be used in prostate cancer PET/SPECT imaging studies .
loading...
    loading...
Cat. No.: HY-126327A
Purity:  ≥98.0%
Research Areas:  

Cancer

UNC4976 TFA is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 TFA simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .
loading...
    loading...
Cat. No.: HY-W1049092
mPEG2000-N3 can be used to modify proteins, peptides, and other materials. The azide group can react with alkynes in aqueous solution catalyzed by copper. It can also be easily reduced to an amine group. PEGylation can increase solubility and stability and reduce the immunogenicity of peptides and proteins. mPEG2000-N3 can also inhibit the nonspecific binding of charged molecules to the modified surface .
loading...
    loading...
Cat. No.: HY-115749
CAS No.: 24404-90-8
Purity:  99.93%
Synonyms: 6′-Methoxyluciferin
Target:  

Fluorescent Dye

Research Areas:  

Others

D-Luciferin 6′-methyl ether (6′-Methoxyluciferin; compound 19a) is a potent luciferase from the North American firefly Photinus pyralis (PpyLuc) inhibitor with an IC50 of 0.1 µM. D-Luciferin 6′-methyl ether, a D-luciferin analog, shows non-specific interactions at ATP- and luciferin-binding sites of the PpyLuc active site .
loading...
    loading...
Cat. No.: HY-106055
CAS No.: 74817-61-1
Murabutide is an immunomodulator and also a NOD2 receptor agonist . Murabutide enhances the signal transduction of ATR and NOD2, mediates the activation of the DDR pathway, and thereby repairs radiation-induced DNA double-strand breaks. Murabutide inhibits radiation-induced cell apoptosis and protects cells and mice from radiation-induced toxic damage. Murabutide induces the expression and DNA-binding activity of Oct-1 in macrophages, thereby inhibiting the transcription and replication of HIV-1. Murabutide reduces the expression levels of CD4 and CCR5 on the surface of macrophages, and induces the secretion of β-chemokines, TNF-α and IL-6. Murabutide enhances non-specific viral resistance and targets reticuloendothelial cells. Murabutide can be used in research related to radiation-induced damage and human immunodeficiency virus type 1 infection .
loading...
    loading...
Cat. No.: HY-160052
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

IL-6 aptamer sodium is an aptamer that specifically binds to IL-6, and can serve as a biological recognition receptor for high-sensitivity detection. IL-6 aptamer sodium enables label-free specific detection through changes in electrical signals of carbon nanotube microarrays or alterations in capacitive impedance on the surface of gold sensors. IL-6 aptamer sodium still maintains high selectivity even below the gray zone threshold for cancer diagnosis, and shows no significant non-specific binding to bovine serum albumin. IL-6 aptamer sodium can form an ordered self-assembled monolayer with 6-mercapto-1-hexanol on gold surfaces, making it suitable for reagent-free capacitive impedance biosensing platforms. IL-6 aptamer sodium is widely used in research related to fields such as cancer, inflammatory diseases, myeloma, liver cancer and glioma .
loading...
    loading...
Cat. No.: HY-126327
CAS No.: 2920299-34-7
Research Areas:  

Cancer

UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .
loading...
    loading...
Cat. No.: HY-W011511
CAS No.: 52009-64-0
3,8-Diamino-6-phenylphenanthridine can bind to DNA by means of a non-specific binding along the DNA exterior .
loading...
    loading...
Cat. No.: HY-P0262
CAS No.: 138579-66-5
Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (KD~40 nM) .
loading...
    loading...
Cat. No.: HY-155471
CAS No.: 608489-42-5
Research Areas:  

Others

IMP 245 is a symmetric di-HSG bivalent hapten. IMP 245 has low toxicity, high affinity binding to available antibodies and absence of cross reactivity or non-specific binding with body components .
loading...
    loading...
Cat. No.: HY-P11351
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

Precursor-HhH is a nucleic acid-binding peptide capable of non-specific interactions with RNA and double-stranded DNA (dsDNA). Precursor-HhH is promising for research of nucleic acid-targeted therapeutics .
loading...
    loading...
Cat. No.: HY-174958A
6-Arm-PEG600-Silane is a silane-modified PEG derivative that can be used to modify glass, silicon or other surfaces by reacting hydroxyl groups with ethoxy (methoxy) silane. PEG can inhibit nonspecific surface binding .
loading...
    loading...