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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
nucleolin
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "nucleolin" in MCE Product Catalog:
10
10 Publications Verification
Synonyms: CX-3543
Target:
Research Areas:
Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template .
1
Cat. No.: HY-177146
CAS No.: 2119034-12-5
Synonyms: MC-Val-Cit-PAB-Paclitaxel
Target:
Research Areas:
Paclitaxel-MVCP (MC-Val-Cit-PAB-Paclitaxel) is a MC-Val-Cit-PAB (HY-78738) and Paclitaxel (HY-B0015) conjugate, and can be used for synthesis of Paclitaxel-nucleolin aptamer conjugate .
Cat. No.: HY-P10997
CAS No.: 536971-53-6
Target:
F3 peptide is a nucleolin-binding tumor-homing peptide that mediates selective uptake and internalization by tumor cells. F3 peptide is a 31-amino acid fragment of human high mobility group nucleosomal protein 2 (HMGN2). F3 peptide inhibits protein synthesis through ribosome inactivation. F3 peptide targets the tumor vasculature. F3 peptide can serve as an effective ligand to improve the druggability of macromolecular drugs or nanoparticles. F3 peptide is used in research on cancers such as glioblastoma and breast cancer .
Cat. No.: HY-172478
DSPE-PEG1000-F3 is a PEG compound which composed of DSPE and a nucleolin targeting peptide (F3). F3 peptide can specifically bind to cell surface nucleolin and undergo an effective cell surface to nucleus transport. DSPE-PEG1000-F3 can be used for drug delivery .
Cat. No.: HY-172479
DSPE-PEG2000-F3 is a PEG compound which composed of DSPE and a nucleolin targeting peptide (F3). F3 peptide can specifically bind to cell surface nucleolin and undergo an effective cell surface to nucleus transport. DSPE-PEG2000-F3 can be used for drug delivery .
Cat. No.: HY-172479A
DSPE-PEG3400-F3 is a PEG compound which composed of DSPE and a nucleolin targeting peptide (F3). F3 peptide can specifically bind to cell surface nucleolin and undergo an effective cell surface to nucleus transport. DSPE-PEG3400-F3 can be used for drug delivery .
0 Images
DNA, d(G-G-T-G-G-T-G-G-T-G-G-T-T-G-T-G-G-T-G-G-T-G-G-T-G-G), triethylamine salt
Cat. No.: HY-147081B
Synonyms: AGRO-100 triethylamine
Cat. No.: HY-118310
CAS No.: 685901-63-7
Xylocydine is an inhibitor of CDK1/2, inhibiting CDK function in various apoptotic processes. Xylocydine specifically blocks CDK1 and CDK2 activity with IC50 of 1.4 nM and 61 nM, respectively. In addition, Xylocydine downregulates phosphorylated nucleolin and retinoblastoma protein levels. .
Cat. No.: HY-P704808
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: nucleolin; Nsr1; Prev. NCL; Protein C23; nucleolin; nucleolin Multifunctional Protein; C23; FLJ45706; MS1116 ; Nucl
Species:
Human
Source:
HEK293
Cat. No.: HY-P704081
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: nucleolin; Nsr1; Prev. NCL; Protein C23; nucleolin; nucleolin Multifunctional Protein; C23; FLJ45706; MS1116 ; Nucl
Species:
Human
Source:
HEK293
Cat. No.: HY-172480
DSPE-PEG5000-F3 is a PEG compound which composed of DSPE and a nucleolin targeting peptide (F3). F3 peptide can specifically bind to cell surface nucleolin and undergo an effective cell surface to nucleus transport. DSPE-PEG5000-F3 can be used for drug delivery .
Cat. No.: HY-P810619
Synonyms: C23; Nsr1
Cat. No.: HY-P810620
Synonyms: C23; Nsr1
Cat. No.: HY-P81695A
Synonyms: C23; Nsr1
Cat. No.: HY-P10997A
Target:
Research Areas:
F3 peptide acetate is a nucleolin-binding tumor-homing peptide that mediates selective uptake and internalization by tumor cells. F3 peptide acetate is a 31-amino acid fragment of human high mobility group nucleosomal protein 2 (HMGN2). F3 peptide acetate inhibits protein synthesis through ribosome inactivation. F3 peptide acetate targets the tumor vasculature. F3 peptide acetate can serve as an effective ligand to improve the druggability of macromolecular drugs or nanoparticles. F3 peptide acetate is used in research on cancers such as glioblastoma and breast cancer .
Cat. No.: HY-111165
CAS No.: 908111-22-8
Research Areas:
SNX-7081 is an Hsp90 inhibitor with Ki and IC50 values of 26 nM and 44 nM, respectively. SNX-7081 blocks the nuclear translocation of NF-κB, inhibits the production of pro-inflammatory cytokines, attenuates the ERK/JNK and PDGF signaling pathways, and suppresses LPS (HY-D1056)-induced nitric oxide production. SNX-7081 inhibits DNA repair, induces G2/M cell cycle arrest, and triggers apoptosis via downregulation of MYC/nucleolin and activation of Fas. SNX-7081 can be used in research related to rheumatoid arthritis and cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
