12

12 Publications Verification

Category:

Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:

Glucocorticoid Receptor Endogenous Metabolite

Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research .

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9

Pimitespib

9 Cited Publications

Cat. No.: HY-15785

CAS No.: 1260533-36-5

Purity: 98.79%

Synonyms: TAS-116

Target:

HSP

Research Areas:

Cancer

Pimitespib (TAS-116) is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (K_is of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94 . Pimitespib demonstrates less ocular toxicity .

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8

Carboxy-PTIO potassium

8 Cited Publications

Cat. No.: HY-18734A

CAS No.: 148819-94-7

Target:

NO Synthase

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology

Carboxy-PTIO potassium is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO₂. Carboxy-PTIO potassium can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model .

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6

Timolol

6 Cited Publications

Cat. No.: HY-17494

CAS No.: 26839-75-8

Synonyms: (S)-L-714,465; MK 950 free base

Target:

Adrenergic Receptor

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect .

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6

Choline chloride

6 Cited Publications

Cat. No.: HY-B1337

CAS No.: 67-48-1

Category:

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:

Histamine Receptor

Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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6

Choline theophyllinate

6 Cited Publications

Cat. No.: HY-B1718

CAS No.: 4499-40-5

Synonyms: Oxtriphylline

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Histamine Receptor

Choline theophyllinate (Oxtriphylline) is an orally active methylxanthine derivative. Choline theophyllinate exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline theophyllinate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. It modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline theophyllinate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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6

Choline (bitartrate)

6 Cited Publications

Cat. No.: HY-101036

CAS No.: 87-67-2

Purity: ≥98.0%

Category:

Animals Ketones, Aldehydes, Acids

Target:

Histamine Receptor

Choline bitartrate (Oxtriphylline) is an orally active methylxanthine-derived choline salt of theophylline. Choline bitartrate exhibits weak antihistaminic and anticholinergic activities and can enhance the effects of histamine and acetylcholine. Choline bitartrate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates central nervous system motor activity, and induces transient hypotension following a pressor phase. Choline bitartrate modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline bitartrate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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5

Diquafosol tetrasodium

5 Cited Publications

Cat. No.: HY-B0606

CAS No.: 211427-08-6

Synonyms: INS365

Target:

P2Y Receptor

Research Areas:

Inflammation/Immunology

Diquafosol tetrasodium is a P2Y2 receptor agonist that stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease.

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4

Travoprost

4 Cited Publications

Cat. No.: HY-B0584

CAS No.: 157283-68-6

Synonyms: Fluprostenol isopropyl ester; AL6221; Flu-Ipr

Target:

Prostaglandin Receptor

Research Areas:

Cardiovascular Disease Endocrinology

Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension .

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4

Proparacaine hydrochloride

4 Cited Publications

Cat. No.: HY-66012

CAS No.: 5875-06-9

Synonyms: Proxymetacaine hydrochloride

Target:

Sodium Channel

Research Areas:

Neurological Disease

Proparacaine (Proxymetacaine) hydrochloride is a local anesthetic. Proparacaine hydrochloride blocks voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting signal conduction and nociceptive signal transmission. Proparacaine hydrochloride blocks nociceptive signals in the eye and induces ocular muscle relaxation to reduce eye movement during surgery. Proparacaine hydrochloride is used in research related to cataracts .

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4

KRFK TFA

4 Cited Publications

Cat. No.: HY-P3970A

Target:

TGF-β Receptor

Research Areas:

Inflammation/Immunology

KRFK TFA, a peptide derived from TSP-1, can activate TGF-β. KRFK TFA promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK TFA can be used for chronic ocular surface inflammatory disorders reseach .

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4

CD63 Protein, Human/Cynomolgus (HEK293, N-His)

4 Cited Publications

Cat. No.: HY-P72715

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: CD63; Tetraspanin-30; Prev. MLA1; AD1 Antigen; TSPAN30; Tspan-30; CD63 Antigen; OMA81H; Pltgp40; Limp1; HOP-26; Lysosomal-Associated Membrane Protein 3; ME491; Lysosome Integral Membrane Protein 1; AD1; Melanoma-Associated Antigen MLA1; ocular Melanoma-As

Species:

Human Cynomolgus

Source:

HEK293

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3

Hydroxocobalamin acetate

3 Cited Publications

Cat. No.: HY-B2209B

CAS No.: 22465-48-1

Synonyms: Vitamin B12a acetate

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

NO Synthase

Hydroxocobalamin acetate is an injectable natural vitamin B12. Hydroxocobalamin acetate binds to NO. Hydroxocobalamin acetate detoxifies Cyanide and NaSH. Hydroxocobalamin acetate reduces hypotension. Hydroxocobalamin acetate is used in research related to vitamin B12 deficiency, including pernicious anemia .

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