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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
optical control
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "optical control" in MCE Product Catalog:
Cat. No.: HY-Z15823
CAS No.: 38321-02-7
Synonyms: Dexverapamil
Research Areas:
(R)-Verapamil (Dexverapamil) is an optically enantiomer of the oral-active Verapamil (HY-14275). (R)-Verapamil has a relatively low affinity for L-type calcium channels (Cav1.2) (IC50 > 300 μM), and its IC50 for sodium channels (sodium channel) is 3.19 μM. (R)-Verapamil exhibits SSTR2 agonistic activity, with an EC50 of 1.3 μM. (R)-Verapamil significantly downregulates the expression of TXNIP protein in diabetic mouse models and significantly inhibits β-cell apoptosis (apoptosis), effectively controlling blood sugar. (R)-Verapamil can be used as a PET tracer for the function of P-glycoprotein (P-gp) .
Cat. No.: HY-139904
CAS No.: 71291-80-0
Target:
Research Areas:
TRPA1 Antagonist 3 is a photoswitchable TRPA1 agonist that enables optical control of the TRPA1 channel.
Cat. No.: HY-120106
CAS No.: 1628784-50-8
BG14 is a chemical optical modulation of epigenetic regulation of transcription (COMET) probe. BG14 enables high-resolution optical control of epigenetic mechanisms using visible light and can photochromically inhibit human histone deacetylases (HDACs). BG14 can be used to study the dynamic regulation of the human genome .
Cat. No.: HY-139340
CAS No.: 2363154-39-4
Research Areas:
Photo-lenalidomide-acid (compound 3) is a photacts consist of a ligand for an E3 ligase, a photoswitch, and a ligand for a protein of interest and enable optical control of protein degradation .
Cat. No.: HY-171002
Target:
Research Areas:
PAD2-IN-2 (cis-isomer of 1) is a protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-2 possess an azobenzene photoswitch to optically control PAD activity. PAD2-IN-2 inhibits histone H3-citrullination .
Cat. No.: HY-171002A
Target:
Research Areas:
PAD2-IN-2 (cis-isomer of 1) TFA is a protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-2 TFA possess an azobenzene photoswitch to optically control PAD activity. PAD2-IN-2 TFA inhibits histone H3-citrullination .
Cat. No.: HY-126424
CAS No.: 2230617-93-1
Target:
Research Areas:
OptoDArG is a photoswitchable diacylglycerol analog that serves as an optical lipid clamp probe. OptoDArG undergoes rapid trans-cis photoisomerization under UV/blue light, with the trans form being inactive, and can be delivered directly to the cell membrane without genetic modification. Cis-OptoDArG regulates the activity of channels such as TRPC3, TRPC6, and TRPL by altering the properties of the cell membrane lipid bilayer, thereby triggering sodium channel-dependent action potentials, PKCα translocation, mechanically sensitive currents, and various other downstream electrophysiological and cellular effects. OptoDArG has activity in identifying lipid-gated pores by controlling TRPC3 channels, and can serve as a tool for studying the lipid-sensing mechanisms of TRPC channels .
Cat. No.: HY-N15775
CAS No.: 2260670-55-9
Synonyms: Azo-Cer
Target:
Cat. No.: HY-119990
CAS No.: 1612189-10-2
Target:
Research Areas:
Fotocaine is a photochromic blocker of voltage-gated ion channels. Fotocaine is readily taken up by neurons in brain slices and enables optical control of action potential firing by switching between 350 and 450 nm light. Fotocaine can be used in analgesia research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
