49

49 Publications Verification

Target:

Research Areas:

Camostat is an orally active trypsin inhibitor. Camostat can reduce pancreatic fibrosis induced by repeated administration of superoxide dismutase inhibitors in rats, and decrease the proliferation and activation of pancreatic stellate cells (PSCs) .

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7

Quinine (hydrochloride)

7 Cited Publications

Cat. No.: HY-110082

CAS No.: 130-89-2

Target:

Flavivirus Dengue Virus Parasite Potassium Channel

Research Areas:

Cardiovascular Disease Infection Cancer

Quinine hydrochloride is an alkaloid extracted from cinchona bark and exhibits oral activity, acting as a potassium channel inhibitor. Quinine hydrochloride modulates the tolerance of red blood cells and presents dose-dependent toxicity and embryonic effects. Quinine hydrochloride is a typical hemolysin that directly lyses red blood cells, with cellular components of red blood cell membranes as its action targets. Quinine hydrochloride disrupts red blood cell membranes and induces hemolysis at high concentrations, while merely weakening the anti-hemolytic capacity of red blood cells at low concentrations. Quinine hydrochloride continuously reduces red blood cell tolerance after in vivo administration, and high doses can also alter blood cell counts. Quinine hydrochloride can be applied to researches related to red blood cell hemolysis, cancer and malaria .

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3

BI 99179

3 Cited Publications

Cat. No.: HY-16100

CAS No.: 1291779-76-4

Target:

Fatty Acid Synthase (FASN)

Research Areas:

Metabolic Disease Cancer

BI 99179, a chemical probe, is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC₅₀ of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats .

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2

LY2940094

2 Cited Publications

Cat. No.: HY-114452

CAS No.: 1307245-86-8

Purity: 99.91%

Synonyms: BTRX-246040

Target:

Opioid Receptor

Research Areas:

Neurological Disease

LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (K_i=0.105 nM) and antagonist potency (K_b=0.166 nM). LY2940094 reduces ethanol self-administration in animal models .

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2

Monascin

2 Cited Publications

Cat. No.: HY-N6641

CAS No.: 21516-68-7

Category:

Natural Products Microorganisms Pigments Plants Other Families Extract Disease Research Fields Inflammation/Immunology Food Research

Target:

Keap1-Nrf2 PPAR

Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor). Monascin is a Nrf2 activator and PPARγ agonist .

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2

LY2940094 tartrate

2 Cited Publications

Cat. No.: HY-114452A

CAS No.: 1307245-87-9

Synonyms: BTRX-246040 tartrate

Target:

Opioid Receptor

Research Areas:

Neurological Disease

LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (K_i=0.105 nM) and antagonist potency (K_b=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models .

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2

Stepronin

2 Cited Publications

Cat. No.: HY-A0234

CAS No.: 72324-18-6

Synonyms: Prostenoglycine; TTPG; Tiase

Target:

Chloride Channel

Research Areas:

Endocrinology

Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl ^- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands .

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2

Levamlodipine

2 Cited Publications

Cat. No.: HY-14744

CAS No.: 103129-82-4

Purity: 98.53%

Synonyms: (S)-Amlodipine; Levoamlodipine

Target:

Calcium Channel MMP

Research Areas:

Cardiovascular Disease Neurological Disease

Levamlodipine ((S)-Amlodipine; Levoamlodipin) is an orally active L-type calcium channel blocker and MMP-9 modulator with high permeability and retention properties. Levamlodipine significantly enhances plaque stability and improves lipid profiles by reducing blood pressure, decreasing systolic blood pressure variability, and inhibiting MMP-9 expression in atherosclerotic plaques. Levamlodipine not only alleviates cardiac and aortic hypertrophy and prevents renal atrophy, but also produces synergistic effects in blood pressure reduction and organ protection when combined with bisoprolol (HY-129029). Levamlodipine exerts no significant inhibitory effect on abdominal aortic intimal hyperplasia. When excessively accumulated in the epidermis, Levamlodipine may induce changes in keratin structure, impair the skin barrier and trigger inflammation; long-term use further exacerbates skin irritation caused by local administration. Levamlodipine can be used in research related to hypertension and atherosclerosis .

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2

Levamlodipine besylate

2 Cited Publications

Cat. No.: HY-14744A

CAS No.: 150566-71-5

Purity: 99.84%

Synonyms: (S)-Amlodipine besylate; Levoamlodipine besylate

Target:

Calcium Channel MMP

Research Areas:

Cardiovascular Disease

Levamlodipine ((S)-Amlodipine; Levoamlodipin) besylate is an orally active L-type calcium channel blocker and MMP-9 modulator with high permeability and retention properties. Levamlodipine besylate significantly enhances plaque stability and improves lipid profiles by reducing blood pressure, decreasing systolic blood pressure variability, and inhibiting MMP-9 expression in atherosclerotic plaques. Levamlodipine besylate not only alleviates cardiac and aortic hypertrophy and prevents renal atrophy, but also produces synergistic effects in blood pressure reduction and organ protection when combined with bisoprolol (HY-129029). Levamlodipine besylate exerts no significant inhibitory effect on abdominal aortic intimal hyperplasia. When excessively accumulated in the epidermis, Levamlodipine besylate may induce changes in keratin structure, impair the skin barrier and trigger inflammation; long-term use further exacerbates skin irritation caused by local administration. Levamlodipine besylate can be used in research related to hypertension and atherosclerosis .

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1

Misoprostol acid

1 Cited Publications

Cat. No.: HY-118189

CAS No.: 112137-89-0

Target:

Prostaglandin Receptor

Research Areas:

Inflammation/Immunology

Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers . Misoprostol is an oral agent used to induce labor .

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1

Apovincaminic acid hydrochloride salt

1 Cited Publications

Cat. No.: HY-133813A

CAS No.: 72296-47-0

Purity: ≥95.0%

Target:

Drug Metabolite

Research Areas:

Cardiovascular Disease Neurological Disease

Apovincaminic acid hydrochloride salt is the major metabolite of Vinpocetine (HY-13295), with blood-brain barrier permeability and oral activity. Apovincaminic acid hydrochloride salt is detectable in the plasma of pregnant rabbits after oral administration of Vinpocetine. Apovincaminic acid hydrochloride salt is absorbable from all segments of the gastrointestinal tract of Norway rat, with the stomach as the primary absorption site, and is excreted via urine and feces. Apovincaminic acid hydrochloride salt is used in the research of cerebrovascular diseases .

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1

AT 1001

1 Cited Publications

Cat. No.: HY-135783

CAS No.: 1314801-63-2

Purity: 99.94%

Target:

nAChR

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology

AT 1001 is an orally effective α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) antagonist with a K_i value of 2.64 nM. AT 1001 reversibly blocks Epibatidine (HY-101078)-induced inward currents in HEK cells transfected with α3β4 nAChR. AT 1001 dose-dependently blocks nicotine self-administration behavior in rats, alleviates gluten-induced gastrointestinal symptoms, blocks tight junction toxin-induced immune responses, and reduces the incidence of type 1 diabetes in rats. AT 1001 can be used in the research of nicotine addiction and celiac disease .

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1

Naltrexone

1 Cited Publications

Cat. No.: HY-76711

CAS No.: 16590-41-3

Target:

Opioid Receptor

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Naltrexone is an orally active, long-acting opioid receptor (opioid receptor) antagonist. Naltrexone blocks the euphoric effects of exogenous opioids and reduces alcohol craving by blocking opioid receptors (μ, κ, and δ) as well as opioid growth factor receptors. Low doses of Naltrexone are used to relieve chronic pain, treat inflammatory diseases and inhibit tumor growth, while high doses or continuous administration exert pro-inflammatory or pro-proliferative effects. Naltrexone relieves intractable pruritus caused by psoriasis, atopic dermatitis and other conditions, and its combination with Bupropion (HY-B0403) inhibits food craving, thereby reducing body weight .

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