15

15 Publications Verification

Target:

Research Areas:

Oxacillin sodium salt is an orally active synthetic penicillin with good bactericidal activity against staphylococci and other gram-positive pathogens .

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7

L-Isoleucine

7 Cited Publications

Cat. No.: HY-N0771

CAS No.: 73-32-5

Category:

Endocrine diseases Amino acids Plants Other Families Extract Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Other Diseases Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder

Target:

Endogenous Metabolite

L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .

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7

Sitafloxacin hydrate

7 Cited Publications

Cat. No.: HY-B0395C

CAS No.: 163253-35-8

Synonyms: DU6859a hydrate

Target:

Bacterial Antibiotic

Research Areas:

Infection

Sitafloxacin (DU6859a) hydrate is an orally active fluoroquinolone antibiotic (antibiotic) with in vitro activity against a wide range of Gram-positive and -negative bacteria, including anaerobic bacteria, as well as atypical pathogens. Sitafloxacin is used in the study of respiratory tract infections and urinary tract infections .

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7

Sitafloxacin

7 Cited Publications

Cat. No.: HY-B0395

CAS No.: 127254-12-0

Synonyms: DU6859a

Target:

Bacterial Antibiotic

Research Areas:

Infection

Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection .

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5

Cephradine

5 Cited Publications

Cat. No.: HY-B1156

CAS No.: 38821-53-3

Synonyms: Cefradine; SQ-11436

Target:

Bacterial Antibiotic TOPK

Research Areas:

Infection Inflammation/Immunology

Cephradine (Cefradine) is a broad-spectrum and orally active cephalosporin. Cephradine is active against both gram-positive and gram-negative pathogens. Cephradine is effective in eradicating most penicillinase-producing organisms. Cephradine has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK .

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5

Cephradine monohydrate

5 Cited Publications

Cat. No.: HY-128449

CAS No.: 75975-70-1

Purity: 91.53%

Synonyms: Cefradine monohydrate

Target:

Bacterial Antibiotic TOPK

Research Areas:

Infection Inflammation/Immunology

Cephradine (Cefradine) monohydrate is a broad-spectrum and orally active cephalosporin. Cephradine monohydrate is active against both grampositive and gram-negative pathogens and effective in eradicating most penicillinase-producing organisms known to be resistant to penicillin G, penicillin V, and ampicillin. Cephradine monohydrate has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine monohydrate blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK .

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3

Ercalcitriol

3 Cited Publications

Cat. No.: HY-32350

CAS No.: 60133-18-8

Synonyms: 1α,25-Dihydroxy Vitamin D2

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

VD/VDR Drug Metabolite Endogenous Metabolite

Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

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2

Ceftibuten dihydrate

2 Cited Publications

Cat. No.: HY-B0698A

CAS No.: 118081-34-8

Synonyms: Sch-39720 dihydrate

Target:

Beta-lactamase Bacterial Antibiotic

Research Areas:

Infection

Ceftibuten (Sch-39720) dihydrate, an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens .

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2

Temephos

2 Cited Publications

Cat. No.: HY-B1120

CAS No.: 3383-96-8

Synonyms: Temefos

Target:

Insecticide Cholinesterase (ChE) Dengue Virus Flavivirus

Research Areas:

Infection

Temephos (Temefos) is an orally active, blood-brain barrier-permeable organophosphate insecticide and AChE inhibitor. By irreversibly inhibiting AChE to induce cholinergic overactivation, Temephos effectively blocks larval development of Aedes aegypti (yellow fever mosquito) and Aedes albopictus (Asian tiger mosquito), and is commonly used in studies related to Dengue Virus, Zika Virus and other relevant pathogens. Temephos exhibits genotoxicity and neurodevelopmental toxicity, and may also cause liver injury, reproductive system abnormalities and cholinergic poisoning symptoms in mammals. Temephos tends to accumulate in adipose tissues and aquatic organisms, and is excreted via feces after metabolism through oxidation and hydrolysis. Note that CYP-mediated metabolic detoxification may reduce the actual larvicidal efficacy of Temephos against some mosquito species. Temephos can be used in research related to dengue fever, Zika virus disease, chikungunya and dracunculiasis .

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2

Cethromycin

2 Cited Publications

Cat. No.: HY-19655

CAS No.: 205110-48-1

Synonyms: ABT-773; Abbott-195773; A-195773

Target:

Antibiotic Bacterial Parasite TNF Receptor IFNAR Interleukin Related

Research Areas:

Infection Inflammation/Immunology

Cethromycin (ABT-773; Abbott-195773) is an orally effective ketolide antibiotic with broad-spectrum antibacterial activity. Cethromycin binds to domains II/V of the 23S rRNA of the 50S subunit, inhibiting bacterial protein synthesis. Cethromycin can accumulate in lung tissue, alveolar macrophages, epithelial lining fluid, and human polymorphonuclear leukocytes. Cethromycin exhibits potent in vitro activity against a variety of respiratory pathogens, including Mycoplasma pneumoniae. Cethromycin exhibits significant intracellular and pulmonary enrichment and anti-inflammatory effects against mycoplasma pneumonia in mouse models, improving airway obstruction and airway hyperresponsiveness. Cethromycin disrupts the apicoplast and reduces liver-stage parasite burden during the liver stage of Plasmodium berghei. Cethromycin can be used in research related to pneumonia, Staphylococcus aureus infection, gonorrhea, and malaria .

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