79 Results for "

orally bioactive

" in MedChemExpress (MCE) Product Catalog:
Products (79)

79 Results for "orally bioactive" in MCE Product Catalog:

187
Belnacasan
Belnacasan
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187 Publications Verification
Cat. No.: HY-13205
CAS No.: 273404-37-8
Purity:  99.99%
Synonyms: VX-765
Target:  

Caspase

Research Areas:  

Inflammation/Immunology

Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM .
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30
Hesperetin
Hesperetin
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30 Cited Publications
Cat. No.: HY-N0168
CAS No.: 520-33-2
Category:  

Plant Flavonoids Neurological Disease Sunscreen Flavonones Cosmetic Research Other Families Extract Disease Research Fields Cancer

Target:  

p38 MAPK Autophagy Apoptosis Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family

Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor .
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28
Gly-β-MCA
Gly-β-MCA
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28 Cited Publications
Cat. No.: HY-114392
CAS No.: 66225-78-3
Purity:  99.75%
Target:  

FXR Autophagy

Research Areas:  

Metabolic Disease Inflammation/Immunology

Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders .
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10
Bavachinin
Bavachinin
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10 Cited Publications
Cat. No.: HY-N0234
CAS No.: 19879-30-2
Synonyms: 7-O-Methylbavachin; Bavachinin A
Category:  

Leguminosae/Fabaceae Extract Plant Flavonoids Monophenols Flavonones Psoralea corylifolia L. Extract Phenols Disease Research Fields Inflammation/Immunology

Target:  

Amyloid-β PPAR HIF/HIF Prolyl-Hydroxylase

Bavachinin is agonist of pan-peroxisome proliferator-activated receptor (PPAR), with the IC50 value of 21.043 μM, 12.819 μM, and 0.622 μM to PPAR-α, RRAR-β/δ, and PPAR-γ, respectively. Bavachinin is an inhibitor of HIF-1α. Bavachinin exhibits antitumor activity against non-small cell lung cancer by targeting RRAR-γ. Bavachinin is a natural compound with anti-inflammatory and anti-angiogenic activities. Bavachinin has orally bioactivity. .
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7
Ruscogenin
Ruscogenin
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7 Cited Publications
Cat. No.: HY-N0496
CAS No.: 472-11-7
Category:  

Cardiovascular Disease Plant Ophiopogon japonicus (L. f.) Ker Gawl. Extract Liliaceae Extract Disease Research Fields Asparagaceae Extract Steroids

Target:  

NOD-like Receptor (NLR)

Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity .
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6
Niflumic acid
Niflumic acid
0 Images
6 Cited Publications
Cat. No.: HY-B0493
CAS No.: 4394-00-7
Target:  

Chloride Channel COX

Research Areas:  

Inflammation/Immunology Cancer

Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC50 value of 100 nM. Niflumic acid induces apoptosis through caspase-8/Bid/Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis .
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5
8-Gingerol
8-Gingerol
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5 Cited Publications
Cat. No.: HY-N0447
CAS No.: 23513-08-8
Category:  

Plant Monophenols Zingiberaceae Extract Phenols Zingiber officinale Roscoe Extract Disease Research Fields Inflammation/Immunology Cancer

Target:  

TRP Channel Bacterial Apoptosis Autophagy STAT PERK EGFR PI3K Akt mTOR Caspase MMP

8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC50 value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases.
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4
Hydrocortisone hemisuccinate
Hydrocortisone hemisuccinate
0 Images
4 Cited Publications
Cat. No.: HY-B1402
CAS No.: 2203-97-6
Synonyms: Hydrocortisone 21-hemisuccinate
Target:  

Interleukin Related

Research Areas:  

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Endocrinology

Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers .
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4
Hydrocortisone hemisuccinate hydrate
Hydrocortisone hemisuccinate hydrate
0 Images
4 Cited Publications
Cat. No.: HY-B1402A
CAS No.: 83784-20-7
Synonyms: Hydrocortisone 21-hemisuccinate hydrate
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Endocrinology

Hydrocortisone hemisuccinate hydrate (Hydrocortisone 21-hemisuccinate hydrate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate hydrate inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate hydrate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers .
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3
Indole-3-pyruvic acid
Indole-3-pyruvic acid
0 Images
3 Cited Publications
Cat. No.: HY-W028393
CAS No.: 392-12-1
Category:  

Alkaloids Endogenous metabolite Disease Research Fields Inflammation/Immunology Indole Alkaloids

Target:  

Endogenous Metabolite Aryl Hydrocarbon Receptor Interleukin Related COX Bcl-2 Family

Indole-3-pyruvic acid is an orally active ketone analog of tryptophan, and is an aryl hydrocarbon receptor (AHR) agonist. Indole-3-pyruvic acid inhibits p38/MAPK phosphorylation, regulates the tryptophan metabolic pathway, and also possesses protective activities against skin photodamage, as well as anti-inflammatory and anti-anxiety bioactivities in the gut. Indole-3-pyruvic acid can downregulate the expression of IL-1β, IL-6, Cox-2, and Bax to alleviate UVB-induced keratinocyte toxicity. Indole-3-pyruvic acid can activate AHR to promote Tr1 cell differentiation, increase IL-10, and inhibit Th1 cytokine production. Indole-3-pyruvic acid can alter the levels of kynurenine metabolites in the brain, mediating central nervous system-related effects. Indole-3-pyruvic acid can be used in research on skin lesions, colitis, and anxiety .
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3
Fraxetin
Fraxetin
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3 Cited Publications
Cat. No.: HY-N0580
CAS No.: 574-84-5
Category:  

Fraxinus rhynchophylla Hance Extract Plant Coumarins Phenylpropanoids Oleaceae Extract Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Bacterial

Fraxetin is isolated from Fraxinus rhynchophylla Hance and has oral bioactivity. Fraxetin has anti-tumor, antibacterial, antioxidant, and anti-inflammatory effects. Fraxetin can induce cell apoptosis .
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2
5,7,3',4'-Tetramethoxyflavone
5,7,3',4'-Tetramethoxyflavone
0 Images
2 Cited Publications
Cat. No.: HY-N7030
CAS No.: 855-97-0
Category:  

Infection Rutaceae Extract Murraya exotica L. Mant. Extract Plant Flavonoids Flavones Disease Research Fields

Target:  

Fungal Parasite Bacterial

5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling .
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2
IT-901
IT-901
0 Images
2 Cited Publications
Cat. No.: HY-124179
CAS No.: 1584121-99-2
Purity:  99.32%
Target:  

NF-κB

Research Areas:  

Cancer

IT-901 is an orally active and potent NF-κB subunit c-Rel inhibitor with an IC50 of 0.1 μM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively. IT-901, a bioactive naphthalenethiobarbiturate derivative, has the potential for human lymphoid tumors and ameliorate graft-versus-host disease (GVHD) .
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1
Gibberellic acid
Gibberellic acid
0 Images
1 Cited Publications
Cat. No.: HY-N1964
CAS No.: 77-06-5
Synonyms: Gibberellin A3
Category:  

Rutaceae Extract Plant Gibberellins Other Diseases Citrus reticulata Blanco Extract Microorganism Phytohormone Disease Research Fields Agricultural Research

Target:  

Environmental Pollutants Drug Derivative Plant Growth Regulators

Gibberellic acid (GA3) is a natural plant growth regulator with oral bioactivity. Gibberellic acid governs multiple plant developmental events, including seed germination, cell elongation, floral organ formation, and rice spikelet fertility. Gibberellic acid optimizes root morphology and secondary metabolite production in Echinacea purpurea hairy roots, and serves as a bioactive seed priming agent to improve chilling stress tolerance in chickpea. Gibberellic acid mediates modulation of enzyme activity and secondary metabolism in plants and exerts tissue-specific regulatory effects on antioxidant systems and lipid peroxidation in rats. Gibberellic acid can be used in studies of plant growth, metabolism, and abiotic stress responses .
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1
Hydroxycitric acid
Hydroxycitric acid
0 Images
1 Cited Publications
Cat. No.: HY-N1437
CAS No.: 6205-14-7
Category:  

Garcinia gummi-gutta (L.) Roxb. Extract Plant Ketones, Aldehydes, Acids Guttiferae Extract

Target:  

Apoptosis Ferroptosis mTOR DNA/RNA Synthesis Keap1-Nrf2 Ribosomal S6 Kinase (RSK) NF-κB ATP Citrate Lyase AMPK

Hydroxycitric acid is an orally active, multi-target, multi-bioactive organic acid. activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Hydroxycitric acid activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Hydroxycitric acid activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .
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1
Jolkinolide B
Jolkinolide B
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1 Cited Publications
Cat. No.: HY-N0732
CAS No.: 37905-08-1
Category:  

Plant Euphorbia fischeriana Steud. Extract Terpenoids Diterpenoids Disease Research Fields Cancer Euphorbiaceae Extract

Target:  

IAP Akt Caspase NF-κB TGF-beta/Smad JAK Bacterial Apoptosis

Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud with oral activity. Jolkinolide B downregulates XIAP, cIAP1, cIAP2, and phosphorylated Akt, upregulates Smac, activates caspase-3 and caspase-9, and inhibits NF-κB, TGFβ/smad3 and JAK/STAT3 pathways. Jolkinolide B exerts comprehensive biological effects including inducing cancer cell apoptosis, suppressing inflammatory responses, improving lung function, alleviating hepatic steatosis and eliminating intracellular Mycobacterium tuberculosis. Jolkinolide B can be used for the research of leukemia, histiocytic lymphoma, asthma, metabolic dysfunction-associated steatotic liver disease and tuberculosis .
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1
Pinoresinol Diglucoside
Pinoresinol Diglucoside
0 Images
1 Cited Publications
Cat. No.: HY-N0657
CAS No.: 63902-38-5
Category:  

Eucommia ulmoides Oliver Extract Plant Other Diseases Lignans Phenylpropanoids Disease Research Fields Eucommiaceae Extract

Target:  

Free Radical Scavengers NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TGF-beta/Smad Akt mTOR PI3K

Pinoresinol Diglucoside is an orally active lignan with multifunctional bioactivity. Pinoresinol Diglucoside interacts with targets including ALB, HIF1A, GSK3B, BCL2, MARK3, IL6, NF-κB p65, Nrf2, HO-1, and TLR4, and modulates pathways including PI3K-Akt, estrogen, MAPK, Rap1, AKT/mTOR/NF-κB, and TGF-β1/Smads. Pinoresinol Diglucoside regulates osteogenesis, bone resorption, oxidative stress, inflammation, apoptosis, ferroptosis, ferritinophagy, cardiac fibrosis, and vasorelaxation. Pinoresinol Diglucoside can be used for the research of osteoporosis, ischemia/reperfusion-induced brain injury, Alzheimer’s disease, myocardial ischemia-reperfusion injury, chondrodysplasia, diabetic cardiomyopathy, cardiac hypertrophy, hypertension, cisplatin-induced hearing loss, atherosclerotic cardiovascular diseases, and disuse osteoporosis .
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1
ar-Turmerone
ar-Turmerone
0 Images
1 Cited Publications
Cat. No.: HY-N6703
CAS No.: 532-65-0
Synonyms: (+)-ar-Turmerone
Category:  

Plant Zingiberaceae Extract Ketones, Aldehydes, Acids Curcuma longa Extract Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis

ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .
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1
Hydroxycitric acid tripotassium
Hydroxycitric acid tripotassium
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1 Cited Publications
Cat. No.: HY-W338584
CAS No.: 232281-44-6
Tripotassium hydroxycitrate is an orally active, multi-target, multi-bioactive organic acid. Tripotassium hydroxycitrate activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Tripotassium hydroxycitrate activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Tripotassium hydroxycitrate activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .
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1
Notoginsenoside Ft1
Notoginsenoside Ft1
0 Images
1 Cited Publications
Cat. No.: HY-N0910
CAS No.: 155683-00-4
Category:  

Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Extract Triterpenes Plant Terpenoids Other Diseases Disease Research Fields Araliaceae Extract

Target:  

PI3K mTOR Akt Apoptosis p38 MAPK ERK Transmembrane Glycoprotein Glutathione Reductase (GR) Estrogen Receptor/ERR Calcium Channel Ferroptosis G protein-coupled Bile Acid Receptor 1 FXR

Notoginsenoside Ft1 is an orally active bioactive saponin. Notoginsenoside Ft1 inhibits the PI3K/AKT/mTOR signaling pathway, activates the p38 MAPK and ERK1/2 signaling pathways, and increases the proportion of CD8 + T cells, thereby inducing apoptosis and lysosomal cell death in various cancer cells, and promoting angiogenesis. Notoginsenoside Ft1 causes vasodilation by activating glucocorticoid receptors (GR) and estrogen receptor beta (ERβ) in endothelial cells. Notoginsenoside Ft1 increases intracellular Ca 2+ accumulation, reduces cAMP levels by activating a signaling network mediated through P2Y12 receptors, and promotes platelet aggregation, thereby exerting a procoagulant effect. Notoginsenoside Ft1 inhibits ferroptosis (ferroptosis) in renal tubular epithelial cells by activating the TGR5 receptor, thereby demonstrating a renal protective effect. Notoginsenoside Ft1 acts as a TGR5 agonist and an FXR antagonist to combat obesity and insulin resistance .
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