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9 Results for "

osteoblastogenesis

" in MedChemExpress (MCE) Product Catalog:

Products (9)

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ER 50891

1 Cited Publications

Cat. No.: HY-108531

CAS No.: 187400-85-7

Purity: 99.86%

Target:

RAR/RXR

Research Areas:

Metabolic Disease

ER 50891 is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis .

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ER 50891 quarterhydrate

1 Cited Publications

Cat. No.: HY-108531A

Purity: 99.86%

Target:

RAR/RXR

Research Areas:

Cancer

ER 50891 quarterhydrate is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis .

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L-Quebrachitol

Cat. No.: HY-N2375

CAS No.: 642-38-6

Category:

Natural Products Metabolic Disease Plants Other Families Extract Disease Research Fields

Target:

Wnt β-catenin p38 MAPK

L-Quebrachitol is a methoxy analog of inositol that can be isolated from plants. L-Quebrachitol has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway .

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Netoglitazone

Cat. No.: HY-100428

CAS No.: 161600-01-7

Purity: 99.88%

Synonyms: MCC-555; Isaglitazone

Target:

PPAR

Research Areas:

Metabolic Disease

Netoglitazone (MCC-555) is an orally active PPARγ ligand with an EC₅₀ of 8 μM. Netoglitazone mediates cell type-specific functional regulation, and modulates the transcriptional activity of PPARγ as a full agonist, partial agonist or antagonist. Netoglitazone induces adipogenesis, inhibits osteoblastogenesis, alters the weight of extramedullary fat depots and enhances insulin sensitivity. Netoglitazone reduces blood glucose levels. Netoglitazone can be used in research related to type 2 diabetes and non-insulin-dependent diabetes mellitus .

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