Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
outward-open conformation
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "outward-open conformation" in MCE Product Catalog:
Cat. No.: HY-101122
CAS No.: 1610954-97-6
Target:
Research Areas:
LX2761 is an orally active, dual SGLT1/SGLT2 inhibitor with IC50 values of 2.2 nM and 2.7 nM against human SGLT1 and SGLT2, respectively. LX2761 locks human SGLT1 in an outward-open conformation and blocks its putative water permeation pathway. After oral administration, LX2761 is confined exclusively to the intestinal lumen, delays intestinal glucose absorption, regulates intestinal glucose metabolism, increases cecal glucose levels, reduces cecal pH, improves glycemic control and elevates plasma total GLP-1 levels. However, LX2761 induces diarrhea in a dose-dependent manner. LX2761 can be used in diabetes-related research .
Cat. No.: HY-189704
CAS No.: 3088774-28-8
IMP-2380 is a NorA inhibitor that binds to the outward-open conformation of Staphylococcus aureus NorA. IMP-2380 enhances the activity of Ciprofloxacin against Methicillin-resistant (HY-121544) and Methicillin-sensitive Staphylococcus aureus. IMP-2380 inhibits Ciprofloxacin-induced SOS response and reduces prophage induction. IMP-2380 reduces bacterial burden in a mouse MRSA infection model in combination with Ciprofloxacin. IMP-2380 can be used for research on Methicillin-resistant Staphylococcus aureus (MRSA) infection .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
