353

353 Publications Verification

MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red.
Excitation/emission wavelength: 510/580 nm.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

171

BODIPY 581/591 C11

171 Cited Publications

Cat. No.: HY-D1301

CAS No.: 217075-36-0

BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

54

NAD sodium

54 Cited Publications

Cat. No.: HY-B0445A

CAS No.: 20111-18-6

Synonyms: β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium

NAD sodium is an orally effective cofactor and homeostatic regulator. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions that oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria, which indirectly generates ATP. NAD sodium can be used for the research of non-alcoholic fatty liver disease, obesity, and glucose intolerance .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

52

DL-Dithiothreitol

52 Cited Publications

Cat. No.: HY-15917

CAS No.: 3483-12-3

Synonyms: DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol

DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

36

High Sensitivity ECL Kit

36 Cited Publications

Cat. No.: HY-K2005

High Sensitivity ECL Kit enables low picogram detection of antigen by oxidizing luminol in the presence of HRP and peroxide. This reaction produces a prolonged chemiluminescence which can be visualized on X-ray film or digital imaging systems. The 100 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

loading...

Please select quantity

August 31

Get Quote

View All Sizes

28

Dihydrorhodamine 123

28 Cited Publications

Cat. No.: HY-101894

CAS No.: 109244-58-8

Purity: 99.83%

Synonyms: DHR 123

Target:

Fluorescent Dye

Research Areas:

Others

Dihydrorhodamine 123 (DHR 123) is a non-fluorescent reactive oxygen species (ROS) indicator. Dihydrorhodamine 123 is oxidized to fluorescent Rhodamine 123 (HY-D0816) within cells in the presence of reactive oxygen species and it localizes in mitochondria (Ex/Em = 515/536 nm).

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

26

IU1

26 Cited Publications

Cat. No.: HY-13817

CAS No.: 314245-33-5

Purity: 99.30%

Target:

Deubiquitinase Autophagy Apoptosis

Research Areas:

Cardiovascular Disease Neurological Disease Endocrinology Cancer

IU1 is a selective, reversible USP14 inhibitor with an IC₅₀ of 4-5 μM. IU1 binds USP14’s catalytic cleft to block deubiquitinase activity. IU1 induces calpain-dependent Tau cleavage, causes ATP deficits, reduces E1~Ub thioester levels and 26S proteasome assembly. IU1 enhances 26S proteasome chymotrypsin-like activity, modulates LC3B-dependent autophagy flux, reduces cancer cell proliferation and migration, and blocks G0/G1 to S phase cell cycle transition in follicular thyroid cancer cells. IU1 activates autophagy-lysosomal and ubiquitin-proteasome pathways, triggers apoptosis, and reduces cervical cancer cell growth. IU1 enhances degradation of proteasome substrates linked to neurodegenerative disease, accelerates oxidized protein degradation, and increases oxidative stress resistance. IU1 can be used for the research of Alzheimer’s disease, follicular thyroid cancer, ischemic stroke, cervical cancer, and neurodegenerative disease .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

21

GSH/GSSG Assay Kit

21 Cited Publications

Cat. No.: HY-K0311

MCE GSH/GSSG Assay Kit is suitable for the quantitative determination of reduced and oxidized glutathione (GSH/GSSG) in whole blood, plasma, serum, urine, and tissue and cell extracts.

loading...

Please select quantity

August 31

Get Quote

View All Sizes

16

FINO2

16 Cited Publications

Cat. No.: HY-129457

CAS No.: 869298-31-7

Purity: ≥98.0%

Target:

Ferroptosis

Research Areas:

Cancer

FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

16

Tempo

16 Cited Publications

Cat. No.: HY-W001187

CAS No.: 2564-83-2

Target:

Mitochondrial Metabolism DNA/RNA Synthesis Reactive Oxygen Species (ROS)

Research Areas:

Cancer

Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells .

Compare

loading...