604 Results for "
p450
" in MedChemExpress (MCE) Product Catalog:
Products (604)
604 Results for "p450" in MCE Product Catalog:
36
36 Publications Verification
Cat. No.: HY-17356
CAS No.: 49562-28-9
Target:
Research Areas:
Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
27
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Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.
24
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
19
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Azoxymethane (AOM) is a colon carcinogen which leads to the formation of DNA adducts. Azomethane is a procarcinogen that requires metabolic activation via cytochrome P450 (P450) enzymes (primarily CYP2E1) .
17
17 Cited Publications
Synonyms: 8-Methoxypsoralen; Xanthotoxin; 8-MOP
Target:
