154

Etomoxir

154 Publications Verification

Cat. No.: HY-50202

CAS No.: 124083-20-1

Synonyms: (R)-(+)-Etomoxir

Target:

Carnitine Palmitoyltransferase (CPT) Apoptosis

Research Areas:

Metabolic Disease Cancer

Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

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154

Etomoxir sodium salt

154 Publications Verification

Cat. No.: HY-50202A

CAS No.: 828934-41-4

Synonyms: (R)-(+)-Etomoxir sodium salt

Target:

Carnitine Palmitoyltransferase (CPT) Apoptosis

Research Areas:

Metabolic Disease Cancer

Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig .

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35

K-975

35 Cited Publications

Cat. No.: HY-138565

CAS No.: 2563855-03-6

Purity: 99.89%

Target:

YAP

Research Areas:

Cancer

K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma .

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12

TVB-3166

12 Cited Publications

Cat. No.: HY-120394

CAS No.: 1533438-83-3

Purity: 99.69%

Target:

Fatty Acid Synthase (FASN) Apoptosis

Research Areas:

Cancer

TVB-3166 is an orally-available, reversible, and selective fatty acid synthase (FASN) inhibitor with IC₅₀s of 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth .

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6

TVB-3664

6 Cited Publications

Cat. No.: HY-120062

CAS No.: 2097262-58-1

Purity: 99.76%

Target:

Fatty Acid Synthase (FASN)

Research Areas:

Cancer

TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor, with IC₅₀ values of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively. TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression .

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3

Ascorbyl palmitate

3 Cited Publications

Cat. No.: HY-B0987

CAS No.: 137-66-6

Synonyms: L-Ascorbic acid 6-hexadecanoate; 6-O-Palmitoyl-L-ascorbic acid

Category:

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:

Environmental Pollutants Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Bcl-2 Family Caspase Calcium Channel NOD-like Receptor (NLR) Sodium Channel

Ascorbyl palmitate is an orally active ester formed from ascorbic acid and palmitic acid, used as an antioxidant and food additive. Ascorbyl palmitate in preventing fat and oil oxidation is more efficient than Butylated hydroxyanisole (HY-B1066) and Butylated hydroxytoluene (HY-Y0172). Ascorbyl palmitate mitigates inhibition of collagen synthesis by select calcium and sodium channel blockers. Ascorbyl palmitate induces Apoptosis in human umbilical vein endothelial cells (HUVECs). Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome .

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3

DC260126

3 Cited Publications

Cat. No.: HY-101906

CAS No.: 346692-04-4

Purity: 99.57%

Target:

Free Fatty Acid Receptor Apoptosis

Research Areas:

Metabolic Disease

DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca ²⁺ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC₅₀: 6.28, 5.96, 7.07, 4.58 μM, respectively) . DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis .

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3

1,2-DLPC

3 Cited Publications

Cat. No.: HY-107737

CAS No.: 18194-25-7

Purity: ≥98.0%

Synonyms: 1,2-Dilauroyl-sn-glycero-3-phosphocholine

Target:

Liposome Apoptosis TNF Receptor PPAR

Research Areas:

Metabolic Disease

1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells .

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3

AM-1638

3 Cited Publications

Cat. No.: HY-13467

CAS No.: 1142214-62-7

Purity: 99.65%

Target:

Free Fatty Acid Receptor

Research Areas:

Metabolic Disease

AM-1638 is an orally active full agonist of GPR40 (EC₅₀: 0.16 μM). AM-1638 increases the expression of antioxidant molecules (HO-1 and NQO-1). AM1638 blocks Palmitate (HY-N0830)-mediated superoxide production and ER stress. AM-1638 has antidiabetic activity and improves glycemic control in BDF mice with diet-induced obesity (DIO). AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%) .

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