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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
pangenotype
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "pangenotype" in MCE Product Catalog:
Synonyms: MK-8408
Target:
Research Areas:
Ruzasvir (MK-8408) is a potent, pan-genotype HCV NS5A inhibitor that blocks RNA synthesis, replication, and assembly. Ruzasvir produces additive to synergistic antiviral effects with Bemnifosbuvir (HY-137958A), Grazoprevir (HY-15298), or Uprifosbuvir (HY-103487) analogs, with no antagonism. Ruzasvir can be used for research on HCV infection .
Cat. No.: HY-125182
CAS No.: 2649904-85-6
Target:
Research Areas:
SMCypI C31 is a non-peptidic cyclophilin inhibitor with potent peptidyl-prolyl cis/trans isomerases (PPIase) inhibitory activity (IC50 of 0.1 µM). SMCypI C31 shows pangenotype anti-HCV activity with EC50s ranging from 1.20 to 7.76 μM for genotype 1a, 1b, 2a, 3a, and 5a HCV subgenomic replicons (HCV-SGRs) and chimeric genotype 2a/4a HCV-SGRs. SMCypI C31 disrupts the cyclophilin A-NS5A interaction .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
