882 Results for "

parvalbumin-positive neurons

" in MedChemExpress (MCE) Product Catalog:

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223

Metformin hydrochloride

223 Publications Verification

Cat. No.: HY-17471A

CAS No.: 1115-70-4

Synonyms: 1,1-Dimethylbiguanide hydrochloride

Target:

AMPK Autophagy Mitophagy Apoptosis mTOR

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

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223

Metformin

223 Publications Verification

Cat. No.: HY-B0627

CAS No.: 657-24-9

Synonyms: 1,1-Dimethylbiguanide

Target:

AMPK Autophagy Mitophagy Apoptosis mTOR

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

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Streptomycin

53 Cited Publications

Cat. No.: HY-B1906

CAS No.: 57-92-1

Synonyms: Agrept; Agrimycin; Streptomycin A

Category:

Natural Products Microorganisms

Target:

Environmental Pollutants Antibiotic Bacterial

Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .

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Oxidopamine hydrochloride

52 Cited Publications

Cat. No.: HY-B1081

CAS No.: 28094-15-7

Synonyms: 6-Hydroxydopamine Hydrochloride

Target:

Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase

Research Areas:

Neurological Disease Cancer

Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE₂ synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome .

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Oxidopamine hydrobromide

52 Cited Publications

Cat. No.: HY-B1081A

CAS No.: 636-00-0

Synonyms: 6-Hydroxydopamine hydrobromide; 6-OHDA hydrobromide

Target:

Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase

Research Areas:

Neurological Disease Cancer

Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrobromide is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrobromide promotes COX-2 activation, leading to PGE₂ synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrobromide can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome .

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