1

1 Cited Publications

Category:

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:

Norcholic acid is a normal minorbile C23 bile acid having four side chain and exsits in human urine and meconium. Norcholic acid can become prominent under certain pathological conditions. Norcholic acid is efficiently absorbed from intestine and quickly excreted into the bile but not into urine .

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Zandatrigine

1 Cited Publications

Cat. No.: HY-147423

CAS No.: 2154406-04-7

Purity: 99.28%

Synonyms: NBI-921352; XEN901

Target:

Sodium Channel

Research Areas:

Neurological Disease

Zandatrigine (NBI-921352; XEN901) is a selective, orally active, voltage-gated sodium channel Na_V1.6/SCN8A inhibitor that can penetrate the blood-brain barrier. Zandatrigine inhibits sodium influx by non-covalently binding to the VSD4 structure of Na_V1.6, blocking the persistent and resuscitative currents under pathological conditions. Zandatrigine can reduce neuronal hyperexcitability and reduce epileptic seizures. Zandatrigine is 134-756-fold selective for other isoforms such as Na_V1.1 and Na_V1.2, and has minimal effect on Na_V1.1 expressed by inhibitory interneurons. Zandatrigine can be used to study Na_V1.6-mediated neuroexcitability diseases such as SCN8A-related developmental epileptic encephalopathy (SCN8A-DEE) and adult focal epilepsy .

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(D-Pro7)-Angiotensin I/II (1-7)

1 Cited Publications

Cat. No.: HY-P1656

CAS No.: 586962-44-9

Target:

Angiotensin Receptor Mas-related G-protein-coupled Receptor (MRGPR)

Research Areas:

Cardiovascular Disease

(D-Pro7)-Angiotensin I/II (1-7) is a potent Mas receptor inhibitor with a K_i of 0.001 μM for rat receptors. (D-Pro7)-Angiotensin I/II (1-7) competitively blocks the binding of Angiotensin-(1-7) to the Mas receptor and attenuates the vasodilatory effect of rat aortas under physiological and hypertensive conditions. (D-Pro7)-Angiotensin I/II (1-7) can be used for studies on the function of the renin-angiotensin system and the pathological mechanisms of hypertension .

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3-Nitro-L-tyrosine

Cat. No.: HY-113248

CAS No.: 621-44-3

Purity: ≥98.0%

Category:

Monophenols Ketones, Aldehydes, Acids Disease markers Metabolic Disease Phenols Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder

Target:

Endogenous Metabolite Adrenergic Receptor Reactive Oxygen Species (ROS)

3-Nitro-L-tyrosine serves as a biomarker of oxidative stress. 3-Nitro-L-tyrosine attenuates the pressor and vasoconstrictive effects of angiotensin II by inhibiting the α₁-adrenergic receptor-mediated signaling pathway, and participates in hemodynamic regulation under pathological conditions such as inflammation and ischemia. 3-Nitro-L-tyrosine can be used in studies related to atherosclerosis, ischemia-reperfusion and sepsis .

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Creatine-d3 hydrate

Cat. No.: HY-W010388AS

CAS No.: 284664-86-4

Creatine-d₃ (hydrate) is a deuterium labeled Creatine hydrate. Creatine hydrate is pivotal in energy metabolism of muscle and brain cells, both in physiological and in pathological conditions .

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Beta-Cortol

Cat. No.: HY-113418

CAS No.: 667-65-2

Purity: ≥99.0%

Category:

Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:

Endogenous Metabolite

Beta-Cortol is an O-glycosylated compound and cortisol metabolite. It can be isolated from the leaves of mulberry cultivar Yu 711, and its concentration decreases significantly when the plant is subjected to drought stress. Beta-Cortol serves as a biomarker, as serum Beta-Cortol levels in early non-small cell lung cancer models are downregulated to 1/8 of the preoperative level after tumor resection. Due to such dramatic changes under specific pathological conditions, Beta-Cortol is currently widely used in studies related to early non-small cell lung cancer .

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DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW

Cat. No.: HY-177204

Target:

Exosomes Ferroptosis Apoptosis Glutathione Peroxidase

Research Areas:

Cardiovascular Disease

DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW is a polypeptide targeting tenascin-X (Tenascin-X) that can be conjugated with liposomes and exosomes. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW specifically binds to Tenascin-X on the surface of cardiomyocytes, mediates receptor-dependent uptake of nanocarriers, enhances targeted drug delivery of cargo to cardiomyocytes, and increases drug accumulation in cardiac tissue. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW protects cardiomyocytes treated with LPS, alleviates oxidative stress, repairs mitochondrial function, inhibits ferroptosis and apoptosis, and downregulates the secretion of pro-inflammatory cytokines at the same time. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW improves cardiac injury and pathological morphology in mice with sepsis-induced cardiomyopathy, restores GPX4 expression, and promotes the internalization of cardiomyocyte-derived exosomes, making it suitable for related research on sepsis-induced cardiomyopathy, myocardial ischemia-reperfusion injury, and other conditions .

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