3

2-Iodomelatonin

3 Cited Publications

Cat. No.: HY-101176

CAS No.: 93515-00-5

Purity: ≥99.0%

Target:

Melatonin Receptor

Research Areas:

Cancer

2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a K_i value of 28 pM, it is more 5-fold selective for MT₁ over MT₂ . 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues .

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Barnidipine hydrochloride

Cat. No.: HY-107322

CAS No.: 104757-53-1

Purity: 99.96%

Synonyms: Mepirodipine hydrochloride; YM-09730-5

Target:

Calcium Channel

Research Areas:

Cardiovascular Disease

Barnidipine (Mepirodipine) hydrochloride is an L-type calcium antagonist (CaA) with high affinity for [ ³H] initrendipine binding sites (K_i = 0.21 nmol/L, has selective action against CaA receptors. Barnidipine hydrochloride is an orally active antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance .

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Arbemnifosbuvir

Cat. No.: HY-156597

CAS No.: 1998705-63-7

Purity: 99.88%

Synonyms: AT-752 free base

Target:

SARS-CoV Dengue Virus RNA MTase Drug Intermediate

Research Areas:

Infection

Arbemnifosbuvir (AT-752 free base) is an orally active inhibitor of DENV NS5 RdRp and MTase, and is also a guanosine nucleotide analog prodrug. Arbemnifosbuvir forms the active triphosphate metabolite AT‑9010 (HY-139165) in peripheral blood mononuclear cells, which competes with GTP to terminate RNA synthesis and binds to the GTP/RNA-cap site to inhibit 2'-O-methylation. Arbemnifosbuvir reduces viremia, improves survival, prevents weight loss, and decreases viral load in a mouse model of dengue virus. Arbemnifosbuvir can be used for research related to viral infections .

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Barnidipine

Cat. No.: HY-107322A

CAS No.: 104713-75-9

Synonyms: Mepirodipine; YM-09730-5 Free base

Target:

Calcium Channel

Research Areas:

Cardiovascular Disease

Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [ ³H] initrendipine binding sites (K_i = 0.21 nmol/L), has selective action against CaA receptors. Barnidipine is an orally effective antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance .

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(R)-KT109

Cat. No.: HY-126031

CAS No.: 2055172-60-4

Target:

DAGL

Research Areas:

Inflammation/Immunology

(R)-KT109 is a peripherally restricted serine hydrolase inhibitor that cannot cross the blood-brain barrier. (R)-KT109 irreversibly inhibits ABHD6, DAGLα and DAGLβ via carbamoylation of the active-site serine. (R)-KT109 exerts selective inhibitory effects on serine hydrolases in mouse brains, with pIC₅₀ values of 8.6, 9.1 and 8.2 against human ABHD6, DAGLα and DAGLβ, respectively. (R)-KT109 effectively reduces the levels of 2-arachidonoylglycerol, arachidonic acid, eicosanoids and TNF-α. (R)-KT109 is widely used in studies of metabolic syndrome-related diseases and neuroinflammation .

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Huwentoxin-IV TFA

Cat. No.: HY-P1220A

Target:

Sodium Channel

Research Areas:

Neurological Disease

Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV TFA has analgesic effects on animal models of inflammatory and neuropathic pain .

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Barnidipine-d5 hydrochloride

Cat. No.: HY-107322S

CAS No.: 2930289-02-2

Purity: ≥98.0%

Synonyms: Mepirodipine-d₅ hydrochloride; YM-09730-5-d₅ hydrochloride

Barnidipine-d₅ (hydrochloride) is the deuterium labeled Barnidipine hydrochloride. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors .Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action .

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Barnidipine-d5

Cat. No.: HY-107322AS1

CAS No.: 2771469-19-1

Purity: 98.97%

Synonyms: Mepirodipine-d5; YM-09730-5-d5 Free base

Barnidipine-d₅ is the deuterium-labeled Barnidipine (HY-107322A). Barnidipine-d₅ (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [ ³H] initrendipine binding sites (K_i=0.21 nmol/l), has selective action against CaA receptors . Barnidipine-d₅ (Mepirodipine) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action .

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AP2238

Cat. No.: HY-119292

CAS No.: 553681-56-4

Target:

Cholinesterase (ChE) Amyloid-β

Research Areas:

Neurological Disease

AP2238 is a dual-function acetylcholinesterase (AChE) inhibitor with K_i values for human AChE (HuAChE) and butyrylcholinesterase (BuChE) of 21.7 and 48.9 μM respectively. AP2238 blocks the pro-fibrotic interaction between the peripheral site of AChE and Aβ, and can inhibit Aβ aggregation. AP2238 can be used for the research of Alzheimer's disease .

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Huwentoxin-IV

Cat. No.: HY-P1220

CAS No.: 526224-73-7

Target:

Sodium Channel

Research Areas:

Neurological Disease

Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain .

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