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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
peroxiredoxin
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "peroxiredoxin" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII) . Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease .
3
3 Cited Publications
Cat. No.: HY-P71231
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX1; TDPX2; Prev. PAGA; PAG; Thioredoxin-Dependent Peroxide Reductase 2; Epididymis Secretory Sperm Binding Protein; Thioredoxin-Dependent peroxiredoxin 1; Thioredoxin-Dependent peroxiredoxin; Thioredoxin Peroxidase 2; Natural Killer-Enhancing Factor A
Species:
Human
Source:
E. coli
3
3 Cited Publications
Cat. No.: HY-P71147
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX3; Protein MER5 Homolog; Prev. AOP1; Prx-III; AOP-1; HBC189; Thioredoxin-Dependent Peroxide Reductase, Mitochondrial; Epididymis Secretory Sperm Binding Protein; Thioredoxin-Dependent peroxiredoxin 3; peroxiredoxin-3; Antioxidant Protein 1; PRO1748; S
Species:
Human
Source:
E. coli
2
Target:
Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
2
2 Cited Publications
Cat. No.: HY-P71232
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX4; peroxiredoxin-4; peroxiredoxin 4; Prx-IV; AOE37-2; Epididymis Secretory Sperm Binding Protein Li 97n; Thioredoxin-Dependent Peroxide Reductase A0372; Thioredoxin Peroxidase (Antioxidant Enzyme); Thioredoxin-Dependent peroxiredoxin 4; Thioredoxin-Dependent peroxiredoxin; Thioredoxin Peroxidase AO372; HEL-S-97n; Antioxidant Enzyme AOE372; AOE372; peroxiredoxin IV; PRX-4
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P73375
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX5; B166; peroxiredoxin 5; Thioredoxin-Dependent peroxiredoxin 5; AOEB166; peroxiredoxin-5, Mitochondrial; ACR1; Alu Co-Repressor 1; PLP; peroxiredoxin V; Peroxisomal Antioxidant Enzyme; MGC142285; Liver Tissue 2D-Page Spot 71B; MGC117264; Thioredoxin
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P71145
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX6; PRX; peroxiredoxin 6; P29; AiPLA2; Red Blood Cells Page Spot 12; NSGPx; Lyso-PC Acyltransferase 5; AOP2; LPC Acyltransferase 5; Acidic Calcium-Independent Phospholipase A2; Antioxidant Protein 2; Lysophosphatidylcholine Acyltransferase 5; Liver 2D
Species:
Human
Source:
E. coli
Research Areas:
CCW16 is a non-selective cysteine-reactive covalent ligand and an RNF4 E3 ubiquitin ligase recruiter with an IC50 of 1.8 μM against human RNF4[. CCW16 covalently modifies accessible cysteine residues on RNF4, PRDX1, PRDX2, and PRDX6, attenuating the peroxide-scavenging activity of peroxiredoxins. CCW16 induces oxidative stress through upregulation of HMOX1 and NRF2, and triggers ferroptosis via lipid peroxidation and ROS signaling pathways in an RNF4-independent manner. CCW16 serves as an RNF4-recruiting moiety; it does not induce RNF4 degradation when used alone and can be used to synthesize protein degraders, such as the PROTAC compound CCW 28-3 (HY-156774). CCW16 can be used for research on acute myeloid leukemia and hepatocellular carcinoma .
Cat. No.: HY-B1324A
CAS No.: 64211-45-6
Synonyms: Ro 13-8996 free base
Target:
Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
Cat. No.: HY-W671129
CAS No.: 68930-68-7
Category:
Target:
Cat. No.: HY-170488
CAS No.: 2925046-28-0
Target:
CM-728 is a oxazepine-naphthoquinone that has cytotoxic and bactericidal effect. CM-728 is a human peroxiredoxin-1 inhibitor. CM-728 is an oxidative stressor that affects mitochondrial function .
Cat. No.: HY-B1324R
CAS No.: 64211-46-7
Synonyms: Ro 13-8996 (Standard)
Oxiconazole nitrate (Standard) is the analytical standard of Oxiconazole nitrate. This product is intended for research and analytical applications. Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
Cat. No.: HY-158368
CAS No.: 2566976-43-8
Research Areas:
PRDX1-IN-2 (compound 15) is a selective inhibitor of the antioxidant enzyme Peroxiredoxin 1 (PRDX1) (IC50=0.35 μM). PRDX1-IN-2 decreases the mitochondria membrane potential of SW620 cells, probably due to ROS induced by PRDX1 inhibition, leading to cell apoptosis. PRDX1-IN-2 can be used for colorectal cancer research .
Cat. No.: HY-177477
CAS No.: 21056-79-1
Target:
Research Areas:
2,5-Epidithia-3,6-dioxopiperazine (Formula 15) is a derivative of Epidithiodioxopiperazine (ETP). 2,5-Epidithia-3,6-dioxopiperazine improves intracellular penetration and restores the activity of 2-Cys-Prx (especially Peroxiredoxin II (PrxII)) of form simulation in cells. 2,5-Epidithia-3,6-dioxopiperazine inhibits PDGF-induced proliferation and migration in vascular smooth muscle cells while promoting these actions in endothelial cells with VEGF induction. 2,5-Epidithia-3,6-dioxopiperazine effectively inhibits the proliferation and migration and lung metastasis of melanoma cells. 2,5-Epidithia-3,6-dioxopiperazine can be used for vascular diseases such as hypertension, angina pectoris and myocardial infarction research .
Cat. No.: HY-P73711
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX5; B166; peroxiredoxin 5; Thioredoxin-Dependent peroxiredoxin 5; AOEB166; peroxiredoxin-5, Mitochondrial; ACR1; Alu Co-Repressor 1; PLP; peroxiredoxin V; Peroxisomal Antioxidant Enzyme; MGC142285; Liver Tissue 2D-Page Spot 71B; MGC117264; Thioredoxin
Species:
Human
Source:
E. coli
Cat. No.: HY-P71146
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX5; B166; peroxiredoxin 5; Thioredoxin-Dependent peroxiredoxin 5; AOEB166; peroxiredoxin-5, Mitochondrial; ACR1; Alu Co-Repressor 1; PLP; peroxiredoxin V; Peroxisomal Antioxidant Enzyme; MGC142285; Liver Tissue 2D-Page Spot 71B; MGC117264; Thioredoxin
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
