135

Nocodazole

135 Publications Verification

Cat. No.: HY-13520

CAS No.: 31430-18-9

Purity: 99.59%

Synonyms: Oncodazole; R17934

Target:

Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis

Research Areas:

Cancer

Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

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34

2-Methoxyestradiol

34 Cited Publications

Cat. No.: HY-12033

CAS No.: 362-07-2

Purity: 99.76%

Synonyms: 2-ME2; NSC-659853

Category:

Monophenols Disease markers Endocrine diseases Phenols Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Endogenous Metabolite Microtubule/Tubulin HIF/HIF Prolyl-Hydroxylase Cytochrome P450 JNK Caspase Estrogen Receptor/ERR Reactive Oxygen Species (ROS) Apoptosis Autophagy

2-Methoxyestradiol (2-ME2; NSC-659853) is an endogenous steroid metabolite generated from 17β-estradiol, possessing various activities such as antitumor and antiangiogenic effects. 2-Methoxyestradiol competitively binds to the colchicine-binding site of tubulin (tubulin), interfering with microtubule assembly dynamics. 2-Methoxyestradiol inhibits CYP1A1/CYP1B1, HIF-1α/2α, and superoxide dismutase, activates the JNK signaling pathway, elevates ROS levels, and induces cell cycle arrest and apoptosis (apoptosis). 2-Methoxyestradiol is used in cancer-related research, such as breast cancer, prostate cancer, and multiple myeloma .

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11

EGTA-AM

11 Cited Publications

Cat. No.: HY-D0973

CAS No.: 99590-86-0

Synonyms: EGTA Acetoxymethyl ester

EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca ²⁺ chelator with slow chelating dynamics.

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6

RT-AM

6 Cited Publications

Cat. No.: HY-108715A

CAS No.: 2280796-94-1

Purity: 98.07%

Target:

Fluorescent Dye

Research Areas:

Neurological Disease

RT-AM is a pro-agent real thiol. Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione dynamics in living cells.

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3

PCC0208017

3 Cited Publications

Cat. No.: HY-139604

CAS No.: 2623158-64-3

Purity: 99.56%

Target:

MARK Apoptosis

Research Areas:

Cancer

PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC₅₀s of 1.8 and 2.01 nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC₅₀s of 31.4 and 33.7 nM, respectively. PCC0208017 suppresses glioma progression in vitro and in vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis. PCC0208017 demonstrates robust antitumor activity in vivo and displays good BBB permeability .

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2

ANS

2 Cited Publications

Cat. No.: HY-D0896

CAS No.: 82-76-8

Synonyms: ANSA; 8-Anilino-1-naphthalenesulfonic acid

ANS (8-Anilino-1-naphthalenesulfonic acid) is a competitive inhibitor targeting thyroxine binding globulin (TBG) (K_i=2.09×10 ⁶ M ^-1). ANS is used in radioimmunoassay by displacing bound triiodothyronine (T3) to improve detection sensitivity. ANS can block the protein binding site of T3 and release free T3 for antibody recognition. As a fluorescent probe, ANS can specifically bind to the hydrophobic region of proteins (such as membrane proteins) and monitor the dynamics of protein conformation through changes in fluorescent signals. It is widely used in biochemical research and antibacterial material development .

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