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28 Results for "

phencyclidine

" in MedChemExpress (MCE) Product Catalog:

Products (28)

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BD-1047 dihydrobromide

14 Publications Verification

Cat. No.: HY-16996A

CAS No.: 138356-21-5

Target:

Sigma Receptor

Research Areas:

Neurological Disease

BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors. BD-1047 dihydrobromide attenuates Apomorphine (HY-12723)-induced climbing and Phencyclidine-induced head twitches .

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CP-809101 hydrochloride

2 Cited Publications

Cat. No.: HY-15543A

CAS No.: 1215721-40-6

Purity: 99.37%

Target:

5-HT Receptor

Research Areas:

Neurological Disease

CP-809101 hydrochloride is a potent and highly selective 5-HT_2C receptor agonist, with pEC₅₀s of 9.96, 7.19 and 6.81 M for human 5HT_2C, 5HT_2B and 5HT_2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence .

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Orphenadrine

Cat. No.: HY-157959

CAS No.: 83-98-7

Synonyms: (±)-Orphenadrine

Target:

iGluR Cytochrome P450 Cholinesterase (ChE)

Research Areas:

Neurological Disease Cancer

Orphenadrine ((±)-Orphenadrine) is a skeletal muscle relaxant and NMDA antagonist that also has antiparkinsonian, antihistamine, antitremor, antispasmodic, and analgesic effects. Orphenadrine inhibits the binding of ^[3H]MK-801 to the phencyclidine (PCP) binding site of the NMDA receptor. Orphenadrine is also an anticholinergic and CYP2B inducer. Orphenadrine may exert pro-tumor effects, causing CAR nuclear translocation, resulting in microsomal reactive oxygen species (ROS) production and oxidative stress. Orphenadrine also exerts neuronal protection, protecting rat cerebellar granule cells (CGC) from 3-NPA-induced death and has inhibitory potential against neurodegenerative diseases mediated by NMDA receptor overactivation .

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