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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
phosphoribosyl
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "phosphoribosyl" in MCE Product Catalog:
2
2 Cited Publications
GNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC50 of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity .
Cat. No.: HY-W013046
CAS No.: 108321-05-7
Synonyms: PRPP pentasodium
Target:
Cat. No.: HY-N8060A
CAS No.: 68244-58-6
Synonyms: Orotidine monophosphate trisodium; Orotidylic acid trisodium
Synonyms: GMX1777; EB-1627
Teglarinad chloride (GMX1777) is a proagent of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis .
Cat. No.: HY-172919
CAS No.: 2976498-55-0
Target:
Research Areas:
PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) (KD=0.410 nM) and nicotinamide phosphoribosyl transferase (NAMPT) (IC50=2.21 nM). PDEδ/NAMPT IN-1 blocks KRAS-related signal transduction and interferes with the synthesis of nicotinamide adenine dinucleotide (NAD +), inducing apoptosis in KRAS mutant pancreatic cancer cells. PDEδ/NAMPT IN-1 is promising for research of KRAS mutant pancreatic cancer .
Cat. No.: HY-CE00612
CAS No.: 175093-25-1
Target:
Research Areas:
2'-(5''-Phosphoribosyl)-3'-dephospho-CoA is an adenosine 5'-phosphate derivative that has the structure of coenzyme A dephosphorylated at C-3' and with a 5''-phospho-D-ribosyl substituent at C-2'.
Cat. No.: HY-CE01933
Synonyms: Acetyl-2'-(5''-phosphoribosyl)-3'-dephospho-coenzyme A
Target:
Research Areas:
Acetyl-2'-(5''-phosphoribosyl)-3'-dephospho-CoA (Acetyl-2'-(5''-phosphoribosyl)-3'-dephospho-coenzyme A) is a coenzyme A derivative .
Cat. No.: HY-180763
CAS No.: 36244-83-4
Target:
Cat. No.: HY-P70227
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HPRT1; HGPRTase; Prev. HPRT; Hypoxanthine phosphoribosyltransferase; HGPRT; Testicular Tissue Protein Li 89; Hypoxanthine-Guanine phosphoribosyltransferase; Lesch-Nyhan Syndrome; Hypoxanthine Guanine phosphoribosyl Transferase; Hypoxanthine phosphoribosyl
Species:
Human
Source:
E. coli
Cat. No.: HY-P77156
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRPS2; Testicular Secretory Protein Li 41; phosphoribosyl Pyrophosphate Synthetase 2; Ribose-Phosphate Diphosphokinase; phosphoribosyl Pyrophosphate Synthase II; PPRibP Synthetase; Ribose-Phosphate Pyrophosphokinase 2; PRS II; Ribose-Phosphate Diphosphoki
Species:
Human
Source:
E. coli
Cat. No.: HY-E71014
Target:
Research Areas:
Orotidine-5'-monophosphate pyrophosphorylase, Brewer's bottom yeast (EC 2.4.2.10) is an enzyme involved in pyrimidine biosynthesis. Orotidine-5'-monophosphate pyrophosphorylase, Brewer's bottom yeast (EC 2.4.2.10) catalyzes the formation of orotidine 5'-monophosphate (OMP) from orotate and phosphoribosyl pyrophosphate.
Cat. No.: HY-P71108
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRPS2; Testicular Secretory Protein Li 41; phosphoribosyl Pyrophosphate Synthetase 2; Ribose-Phosphate Diphosphokinase; phosphoribosyl Pyrophosphate Synthase II; PPRibP Synthetase; Ribose-Phosphate Pyrophosphokinase 2; PRS II; Ribose-Phosphate Diphosphoki
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
