5 Results for "

phosphorylated RB

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "phosphorylated RB" in MCE Product Catalog:

A-800141
A-800141
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Cat. No.: HY-119062
CAS No.: 681245-85-2
Target:  

MetAP CDK

Research Areas:  

Cancer

A-800141 is an orally active, selective, sulfonamide-based MetAP2 inhibitor (IC50=12 nM) that binds reversibly to MetAP2 and interacts with its manganese ions. A-800141 induces the production of N-terminal methionine-unprocessed GAPDH variants, which in turn triggers G1-phase cell cycle arrest, elevates p21 levels, and reduces the levels of phosphorylated Rb and total cyclin A. A-800141 exhibits anti-angiogenic and tumor growth inhibitory effects, and produces synergistic effects when combined with cytotoxic inhibitors or BCL-2 inhibitors. A-800141 has been widely used in scientific research related to B-cell lymphoma, neuroblastoma, prostate cancer, colon cancer, melanoma and other fields .
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Pancracine
Pancracine
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Cat. No.: HY-N20721
CAS No.: 21416-14-8
Category:  

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