78

Oseltamivir acid

78 Publications Verification

Cat. No.: HY-13318

CAS No.: 187227-45-8

Purity: 99.50%

Synonyms: GS 4071; Ro 64-0802; Oseltamivir carboxylate

Target:

Influenza Virus Drug Metabolite

Research Areas:

Infection Neurological Disease

Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC₅₀=2 nM) with activity against both influenza A and B viruses. Oseltamivir acid has an extremely weak ability to penetrate the BBB under normal physiological conditions, but its blood-brain barrier penetration is significantly enhanced under inflammatory conditions .

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22

Histamine

22 Cited Publications

Cat. No.: HY-B1204

CAS No.: 51-45-6

Synonyms: Ergamine

Category:

Human Gut Microbiota Metabolites Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Histamine Receptor p38 MAPK Akt Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite

Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

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22

Histamine dihydrochloride

22 Cited Publications

Cat. No.: HY-B0722

CAS No.: 56-92-8

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Histamine Receptor p38 MAPK Akt Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite

Histamine dihydrochloride is the agonist for histamine receptor and a vasodilator. Histamine dihydrochloride is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine dihydrochloride affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

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22

Histamine phosphate

22 Cited Publications

Cat. No.: HY-A0129

CAS No.: 51-74-1

Synonyms: Histamine diphosphate

Category:

Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Histamine Receptor p38 MAPK Akt Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite

Histamine phosphate is the agonist for histamine receptor and a vasodilator. Histamine phosphate is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine phosphate affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine phosphate can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

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22

Hyaluronic acid sodium

22 Cited Publications

Cat. No.: HY-B0633

CAS No.: 9067-32-7

Synonyms: Sodium hyaluronate

Category:

Microorganisms Animals Cosmetic Research Disease Research Fields Saccharides Cancer

Target:

Endogenous Metabolite Bacterial PI3K Akt

Hyaluronic acid sodium (Sodium hyaluronate) is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid sodium is a major component of the extracellular matrix (ECM). Hyaluronic acid sodium is synthesized at the plasma membrane. Increased hyaluronic acid sodium levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid sodium participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid sodium activates the PI3K-Akt signaling. Hyaluronic acid sodium acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid sodium also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid sodium can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid sodium can be studied in joint diseases, wound healing and cancer .

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