4

S1RA

4 Cited Publications

Cat. No.: HY-18099

CAS No.: 878141-96-9

Synonyms: E-52862

Target:

Sigma Receptor 5-HT Receptor

Research Areas:

Neurological Disease

S1RA (E-52862) is a highly selective σ1 receptor (σ1R) antagonist with K_is of 17 nM and 23.5 nM for human σ1R and guinea pig σ1R, respectively. S1RA has Moderate antagonistic activity for human 5-HT_2B receptor (K_i= 328 nM). S1RA has antinociceptive effects in neuropathic pain models. S1RA prevents mechanical and cold hypersensitivity in Oxaliplatin (HY-17371)-treated mice .

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1

Tuberostemonine

1 Cited Publications

Cat. No.: HY-N0352

CAS No.: 6879-01-2

Category:

Infection Alkaloids Pyrrole Alkaloids Plants Other Families Extract Disease Research Fields

Target:

Parasite

Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity against Ferredoxin-NADP ⁺ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine can reduce the number of citric acid-induced coughs in guinea pigs. Tuberostemonine decreases bronchoalveolar lavage fluid (BALF), neutrophil and macrophage infiltration and reduces peribronchial and perivascular inflammatory cell infiltration in mouse model of acute lung inflammation. Tuberostemonine has a level of activity as a feeding deterrent .

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Flavone

Cat. No.: HY-N2424

CAS No.: 525-82-6

Synonyms: 2-Phenyl-4-chromone

Category:

Flavonoids Flavones Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

CDK Apoptosis Caspase

Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21_waf1, PIG3). Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21_waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer .

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GW 833972A

Cat. No.: HY-101765

CAS No.: 1092502-33-4

Purity: 99.91%

Target:

Cannabinoid Receptor

Research Areas:

Neurological Disease Inflammation/Immunology

GW 833972A is a selective CB₂ receptor agonist with pEC₅₀ of the human CB₂ receptor for GW 833972A of 7.3, and its selectivity for the CB₂ receptor is approximately 1000 times higher than that for the CB₁ receptor. GW 833972A inhibits induced neuronal depolarization and suppresses coughing caused by citric acid in guinea pig models. GW 833972A can be used for the study of chronic cough .

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BKI-1369

Cat. No.: HY-121495

CAS No.: 1951431-22-3

Purity: 98.77%

Target:

Parasite

Research Areas:

Infection

BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC₅₀ of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves .

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Bepafant

Cat. No.: HY-121007

CAS No.: 114776-28-2

Synonyms: Web2170

Target:

Platelet-activating Factor Receptor (PAFR)

Research Areas:

Others

Bepafant (Web2170) is a platelet-activating factor (PAF) antagonist that protects against anaphylactic lethality in active and passive anaphylaxis models in mice and guinea pigs in a dose-dependent manner and attenuates bronchoconstriction and blood pressure changes in anaphylaxis.

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Eniporide

Cat. No.: HY-106150

CAS No.: 176644-21-6

Synonyms: EMD-96785

Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest .

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