38

38 Publications Verification

Purity: 99.87%

Synonyms: BMS-986165

Deucravacitinib (BMS-986165) is an orally active allosteric inhibitor of tyrosine kinase 2 (TYK2), with an IC₅₀ of 0.2 nM and a K_i of 0.02 nM against the JH2 domain of TYK2, and it exhibits selectivity over other JAK subtypes and most of the kinome. Deucravacitinib blocks IL-23, IL-12, p-STAT1/3 and Type I IFN signaling, and inhibits Th17/Th1-mediated psoriasis inflammation . Deucravacitinib can be used in research related to moderate-to-severe plaque psoriasis, inflammatory bowel disease and systemic lupus erythematosus .

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32

Thioflavine S

32 Cited Publications

Cat. No.: HY-D0972

CAS No.: 1326-12-1

Synonyms: Thioflavin S; Direct Yellow 7

Thioflavine S is a fluorescent histochemical marker of dense core senile plaques. Thioflavine S can be used for Alzheimer's research .

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16

Etanercept

16 Cited Publications

Cat. No.: HY-108847

CAS No.: 185243-69-0

Purity: 99.20%

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis .

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15

ODN 1826

15 Cited Publications

Cat. No.: HY-146245

CAS No.: 202668-42-6

Purity: 96.86%

Synonyms: CpG 1826

Target:

Toll-like Receptor (TLR) Apoptosis NO Synthase

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

ODN 1826 is a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist. ODN 1826 induces NO and iNOS production and enhances Apoptosis. ODN 1826 enhances immune surveillance. ODN 1826 increases aortic atherosclerotic plaque size. ODN 1826 has antitumor activity against lung cancer, glioma and melanoma .

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15

ODN 1826 sodium

15 Cited Publications

Cat. No.: HY-146245C

Purity: 99.51%

Synonyms: CpG 1826 sodium

Target:

Toll-like Receptor (TLR) Apoptosis NO Synthase

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

ODN 1826 sodium is a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist. ODN 1826 sodium induces NO and iNOS production and enhances Apoptosis. ODN 1826 sodium enhances immune surveillance. ODN 1826 sodium increases aortic atherosclerotic plaque size. ODN 1826 sodium has antitumor activity against lung cancer, glioma and melanoma .

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13

Secukinumab

13 Cited Publications

Cat. No.: HY-P9927

CAS No.: 1229022-83-6

Synonyms: AIN457

Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis .

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12

β-Amyloid (1-40) (human) TFA

12 Cited Publications

Cat. No.: HY-P0265A

Synonyms: Amyloid β-Peptide (1-40) (human) TFA; Aβ40 (human) TFA; Aβ(1-40) (human) TFA

Target:

Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (1-40) TFA is a primary protein in plaques found in the brains of patients with Alzheimer's disease .

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12

β-Amyloid (1-40), HFIP-treated TFA

12 Cited Publications

Cat. No.: HY-P0265C

Target:

Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (1-40), HFIP-treated is a β-Amyloid (1-40) (HY-P0265A) treated with HFIP. β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease .

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11

Ligustrazine

11 Cited Publications

Cat. No.: HY-N0264

CAS No.: 1124-11-4

Synonyms: Chuanxiongzine; Tetramethylpyrazine

Category:

Cardiovascular Disease Natural Products Neurological Disease 500 - Internal Server Error | MedChemExpress

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