76

Amiloride

76 Publications Verification

Cat. No.: HY-B0285

CAS No.: 2609-46-3

Synonyms: MK-870

Target:

Sodium Channel TRP Channel Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease

Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

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76

Amiloride hydrochloride

76 Publications Verification

Cat. No.: HY-B0285A

CAS No.: 2016-88-8

Synonyms: MK-870 hydrochloride

Target:

Sodium Channel TRP Channel Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease

Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

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76

Amiloride hydrochloride dihydrate

76 Publications Verification

Cat. No.: HY-B0285B

CAS No.: 17440-83-4

Synonyms: MK-870 hydrochloride dihydrate

Target:

Sodium Channel Apoptosis TRP Channel

Research Areas:

Cardiovascular Disease Metabolic Disease

Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

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51

Edaravone

51 Cited Publications

Cat. No.: HY-B0099

CAS No.: 89-25-8

Synonyms: MCI-186

Target:

Free Radical Scavengers MMP Apoptosis

Research Areas:

Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer

Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

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18

Tiplaxtinin

18 Cited Publications

Cat. No.: HY-15253

CAS No.: 393105-53-8

Purity: 99.03%

Synonyms: PAI-039; Tiplasinin

Target:

PAI-1 Apoptosis

Research Areas:

Metabolic Disease Cancer

Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC₅₀ of 2.7 μM .

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10

TM5441

10 Cited Publications

Cat. No.: HY-101761

CAS No.: 1190221-43-2

Purity: 99.08%

Target:

PAI-1 Apoptosis

Research Areas:

Cardiovascular Disease Cancer

TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC₅₀ values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence .

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9

LCKLSL

9 Cited Publications

Cat. No.: HY-P2333

CAS No.: 533902-29-3

Target:

Annexin A

Research Areas:

Cardiovascular Disease

LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles .

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9

LCKLSL hydrochloride

9 Cited Publications

Cat. No.: HY-P2333A

Target:

Annexin A

Research Areas:

Cardiovascular Disease

LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL hydrochloride also inhibits the generation of plasmin and has anti-angiogenic roles .

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5

T-PA Protein, Human (HEK293, His)

5 Cited Publications

Cat. No.: HY-P71051

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: PLAT; T-PA; plasminogen Activator, Tissue Type; TPA; Tissue-Type plasminogen Activator; plasminogen Activator, Tissue; T-plasminogen Activator; plasminogen/Activator Kringle; Alteplase; plasminogen Activator; Reteplase

Species:

Human

Source:

HEK293

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4

6-Aminocaproic acid

4 Cited Publications

Cat. No.: HY-B0236

CAS No.: 60-32-2

Synonyms: EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

PAI-1 Plasminogen/Plasmin PROTAC Linkers

6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders .

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